2-Fluoro-5-Trifluoromethylbenzoic Acid

2-Fluoro-5-Trifluoromethylbenzoic Acid Structure
2-Fluoro-5-Trifluoromethylbenzoic Acid structure
Common Name 2-Fluoro-5-Trifluoromethylbenzoic Acid
CAS Number 115029-23-7 Molecular Weight 208.110
Density 1.5±0.1 g/cm3 Boiling Point 235.8±40.0 °C at 760 mmHg
Molecular Formula C8H4F4O2 Melting Point 100-103 °C(lit.)
MSDS Chinese USA Flash Point 96.4±27.3 °C
Symbol GHS07
GHS07
Signal Word Warning

Discovery of XEN445: a potent and selective endothelial lipase inhibitor raises plasma HDL-cholesterol concentration in mice.

Bioorg. Med. Chem. 21(24) , 7724-34, (2013)

Endothelial lipase (EL) activity has been implicated in HDL metabolism and in atherosclerotic plaque development; inhibitors are proposed to be efficacious in the treatment of dyslipidemia related cardiovascular disease. We describe here the discovery of a no...