Fluorothyl
Fluorothyl structure
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Common Name | Fluorothyl | ||
|---|---|---|---|---|
| CAS Number | 333-36-8 | Molecular Weight | 182.06400 | |
| Density | 1.404 g/mL at 25 °C(lit.) | Boiling Point | 62-63 °C(lit.) | |
| Molecular Formula | C4H4F6O | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 35 °F | |
| Symbol |
GHS02, GHS07 |
Signal Word | Danger | |
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Spatiotemporal differences in the c-fos pathway between C57BL/6J and DBA/2J mice following flurothyl-induced seizures: A dissociation of hippocampal Fos from seizure activity.
Epilepsy Res. 109 , 183-96, (2014) Significant differences in seizure characteristics between inbred mouse strains highlight the importance of genetic predisposition to epilepsy. Here, we examined the genetic differences between the seizure-resistant C57BL/6J (B6) mouse strain and the seizure-... |
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Early life status epilepticus and stress have distinct and sex-specific effects on learning, subsequent seizure outcomes, including anticonvulsant response to phenobarbital.
CNS Neurosci. Ther. 21(2) , 181-92, (2015) Neonatal status epilepticus (SE) is often associated with adverse cognitive and epilepsy outcomes. We investigate the effects of three episodes of kainic acid-induced SE (3KA-SE) and maternal separation in immature rats on subsequent learning, seizure suscept... |
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TET1 controls CNS 5-methylcytosine hydroxylation, active DNA demethylation, gene transcription, and memory formation.
Neuron 79(6) , 1086-93, (2013) Dynamic changes in 5-methylcytosine (5mC) have been implicated in the regulation of gene expression critical for consolidation of memory. However, little is known about how these changes in 5mC are regulated in the adult brain. The enzyme methylcytosine dioxy... |
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Prenatal corticosteroid exposure alters early developmental seizures and behavior
Epilepsy Res. 95(1-2) , 9-19, (2011) In humans, corticosteroids are often administered prenatally to improve lung development in preterm neonates. Studies in exposed children as well as in children, whose mothers experienced significant stress during pregnancy indicate behavioral problems and po... |
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Long-term expression of metabolism-associated genes in the rat hippocampus following recurrent neonatal seizures and its regulation by melatonin.
Mol. Med. Report. 12 , 2727-34, (2015) Despite the effective use of antiepileptic drugs (AEDs) for epilepsy, therapeutic failure occurs in 30% of patients. Novel approaches are targeting the inhibition of epileptogenesis. N-acetyl-5-methoxytryptamine (melatonin) is an indoleamine produced mainly b... |
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Prophylactic treatment with melatonin before recurrent neonatal seizures: Effects on long-term neurobehavioral changes and the underlying expression of metabolism-related genes in rat hippocampus and cerebral cortex.
Pharmacol. Biochem. Behav. 133 , 25-30, (2015) Although it has been suggested that the protective effect of melatonin against seizure-induced neurotoxicity involves inhibition of neuronal lipid peroxidation, current data concerning the exact molecular mechanism are still limited. This study was undertaken... |
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Scn1a dysfunction alters behavior but not the effect of stress on seizure response.
Genes. Brain. Behav. 15 , 335-47, (2016) Mutations in the voltage-gated sodium channel gene SCN1A are responsible for a number of epilepsy disorders, including genetic epilepsy with febrile seizures plus (GEFS+) and Dravet syndrome. In addition, dysfunction in SCN1A is increasingly being linked to n... |
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Knock-in mouse model of alternating hemiplegia of childhood: behavioral and electrophysiologic characterization.
Epilepsia 56(1) , 82-93, (2015) Mutations in the ATP1α3 subunit of the neuronal Na+/K+-ATPase are thought to be responsible for seizures, hemiplegias, and other symptoms of alternating hemiplegia of childhood (AHC). However, the mechanisms through which ATP1A3 mutations mediate their pathop... |
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Effects of early malnutrition, isolation and seizures on memory and spatial learning in the developing rat
Int. J. Dev. Neurosci. 28(4) , 303-7, (2010) Purpose In this study we evaluated the effects of undernourishment and seizures on memory and spatial learning in a model of developing brain. |
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An isolated epileptic seizure elicits learning impairment which could be prevented by melatonin.
Epilepsy Behav. 23(3) , 199-204, (2012) We tested the relation between a single short tonic-clonic seizure elicited by flurothyl vapors and changes of learning in Morris water maze (MWM) in Wistar rats. Oxidative stress usually accompanies seizures. Large melatonin doses were applied immediately be... |