Urocanic acid
Urocanic acid structure
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Common Name | Urocanic acid | ||
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| CAS Number | 104-98-3 | Molecular Weight | 138.124 | |
| Density | 1.4±0.1 g/cm3 | Boiling Point | 456.9±20.0 °C at 760 mmHg | |
| Molecular Formula | C6H6N2O2 | Melting Point | 226-228 °C(lit.) | |
| MSDS | Chinese USA | Flash Point | 230.1±21.8 °C | |
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Investigation of a Degradant in a Biologics Formulation Buffer Containing L-Histidine.
Pharm. Res. 32 , 2625-35, (2015) An unknown UV 280 nm absorbing peak was observed by SEC for protein stability samples formulated in L-histidine during a stress stability study. Understanding the source would enhance the confidence in the SEC results. We identified the unknown peak, studied ... |
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Chemical genetics reveals a complex functional ground state of neural stem cells.
Nat. Chem. Biol. 3(5) , 268-273, (2007) The identification of self-renewing and multipotent neural stem cells (NSCs) in the mammalian brain holds promise for the treatment of neurological diseases and has yielded new insight into brain cancer. However, the complete repertoire of signaling pathways ... |
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Development of imidazole alkanoic acids as mGAT3 selective GABA uptake inhibitors.
Eur. J. Med. Chem. 46 , 1483-98, (2011) A new series of potential GABA uptake inhibitors starting from of 1H-imidazol-4-ylacetic acid with the carboxylic acid side chain originating from different positions and varying in length have been synthesized and tested for the inhibitory potency at the fou... |
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Design, RNA cleavage and antiviral activity of new artificial ribonucleases derived from mono-, di- and tripeptides connected by linkers of different hydrophobicity.
Bioorg. Med. Chem. 24 , 1346-55, (2016) A novel series of metal-free artificial ribonucleases (aRNases) was designed, synthesized and assessed in terms of ribonuclease activity and ability to inactivate influenza virus WSN/A33/H1N1 in vitro. The compounds were built of two short peptide fragments, ... |
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Enhanced antitumor efficacies of multifunctional nanocomplexes through knocking down the barriers for siRNA delivery.
Biomaterials 44 , 111-21, (2015) Multifunctional nanocomplexes (NCs) consisting of urocanic acid-modified galactosylated trimethyl chitosan (UA-GT) conjugates as polymeric vectors, poly(allylamine hydrochloride)-citraconic anhydride (PAH-Cit) as charge-reversible crosslinkers, and vascular e... |
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[Membranothropic properties of the urocanic acid].
Ukr. Biokhim. Zh. 85(1) , 42-50, (2013) The effects of urocanic acid (UA) on thermodynamic parameters of model dipalmitoylphosphatidylcholine (DPPC) lipid membrane have been studied by means of differential scanning calorimetry (DSC). The observed ordering effect of UA on the lipid bilayer is refle... |
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Skin barrier abnormality caused by filaggrin (FLG) mutations is associated with increased serum 25-hydroxyvitamin D concentrations.
J. Allergy Clin. Immunol. 130(5) , 1204-1207.e2, (2012)
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Cuts by caspase-14 control the proteolysis of filaggrin.
J. Invest. Dermatol. 131(11) , 2173-5, (2011) Although mutations in the filaggrin gene (FLG) have been shown to be associated with ichthyosis vulgaris and atopic dermatitis, the function and regulation of filaggrin remain incompletely understood. In this issue, Hoste et al. report that filaggrin is direc... |
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Urocanic acid in the skin: a mixed blessing?
J. Invest. Dermatol. 131(1) , 14-7, (2011) Located in the stratum corneum, urocanic acid is a major epidermal chromophore for UVR. This simple molecule has attracted a great deal of research interest over the past half century, initially as a putative "natural sunscreen" and later as a mediator of pho... |
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Antitumor effects of cis-urocanic acid on experimental urothelial cell carcinoma of the bladder.
J. Urol. 187(4) , 1445-9, (2012) We determined the effect of protodynamic therapy against bladder cancer cells in vitro and in vivo. We investigated cis-urocanic acid in rat bladder cancer cell cultures and in an orthotopic rat urothelial carcinoma model to assess its safety and antiprolifer... |