Chorismic acid, from Enterobacter aerogenes
Chorismic acid, from Enterobacter aerogenes structure
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Common Name | Chorismic acid, from Enterobacter aerogenes | ||
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| CAS Number | 617-12-9 | Molecular Weight | 226.18300 | |
| Density | 1.49g/cm3 | Boiling Point | 556.1ºC at 760 mmHg | |
| Molecular Formula | C10H10O6 | Melting Point | 105-108ºC | |
| MSDS | Chinese USA | Flash Point | 225.7ºC | |
| Symbol |
GHS07, GHS08 |
Signal Word | Danger | |
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Complex Formation between Two Biosynthetic Enzymes Modifies the Allosteric Regulatory Properties of Both: AN EXAMPLE OF MOLECULAR SYMBIOSIS.
J. Biol. Chem. 290 , 18187-98, (2015) Allostery, where remote ligand binding alters protein function, is essential for the control of metabolism. Here, we have identified a highly sophisticated allosteric response that allows complex control of the pathway for aromatic amino acid biosynthesis in ... |
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Biosynthesis of salicylic acid in plants.
Plant Signal Behav. 4(6) , 493-6, (2009) Salicylic acid (SA) is an important signal molecule in plants. Two pathways of SA biosynthesis have been proposed in plants. Biochemical studies using isotope feeding have suggested that plants synthesize SA from cinnamate produced by the activity of phenylal... |
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AhpC is required for optimal production of enterobactin by Escherichia coli.
J. Bacteriol. 194(24) , 6748-57, (2012) Escherichia coli alkyl hydroperoxide reductase subunit C (AhpC) is a peroxiredoxin that detoxifies peroxides. Here we show an additional role for AhpC in cellular iron metabolism of E. coli. Deletion of ahpC resulted in reduced growth and reduced accumulation... |
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Accumulation of isochorismate-derived 2,3-dihydroxybenzoic 3-O-beta-D-xyloside in arabidopsis resistance to pathogens and ageing of leaves.
J. Biol. Chem. 285(33) , 25654-65, (2010) An intricate network of hormone signals regulates plant development and responses to biotic and abiotic stress. Salicylic acid (SA), derived from the shikimate/isochorismate pathway, is a key hormone in resistance to biotrophic pathogens. Several SA derivativ... |
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Biosynthesis of the immunosuppressants FK506, FK520, and rapamycin involves a previously undescribed family of enzymes acting on chorismate.
Proc. Natl. Acad. Sci. U. S. A. 108(12) , 4776-81, (2011) The macrocyclic polyketides FK506, FK520, and rapamycin are potent immunosuppressants that prevent T-cell proliferation through initial binding to the immunophilin FKBP12. Analogs of these molecules are of considerable interest as therapeutics in both metasta... |
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Molecular dynamics simulation of the last step of a catalytic cycle: product release from the active site of the enzyme chorismate mutase from Mycobacterium tuberculosis.
Protein Sci. 21(11) , 1672-81, (2012) The protein chorismate mutase MtCM from Mycobacterium tuberculosis catalyzes one of the few pericyclic reactions known in biology: the transformation of chorismate to prephenate. Chorismate mutases have been widely studied experimentally and computationally t... |
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para-Aminobenzoic acid is a precursor in coenzyme Q6 biosynthesis in Saccharomyces cerevisiae.
J. Biol. Chem. 285(36) , 27827-38, (2010) Coenzyme Q (ubiquinone or Q) is a crucial mitochondrial lipid required for respiratory electron transport in eukaryotes. 4-Hydroxybenozoate (4HB) is an aromatic ring precursor that forms the benzoquinone ring of Q and is used extensively to examine Q biosynth... |
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Roles of trpE2, entC and entD in salicylic acid biosynthesis in Mycobacterium smegmatis.
FEMS Microbiol. Lett. 308(2) , 159-65, (2010) Mycobacterium smegmatis acquires extracellular iron using exochelin, mycobactin and carboxymycobactin. The latter two siderophores are synthesized from salicylic acid, which, in turn, is derived from chorismic acid in the shikimic acid pathway. To understand ... |
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Crystal structure of Escherichia coli enterobactin-specific isochorismate synthase (EntC) bound to its reaction product isochorismate: implications for the enzyme mechanism and differential activity of chorismate-utilizing enzymes.
J. Mol. Biol. 397(1) , 290-300, (2010) EntC, one of two isochorismate synthases in Escherichia coli, is specific to the biosynthesis of the siderophore enterobactin. Here, we report the crystal structure of EntC in complex with isochorismate and Mg(2+)at 2.3 A resolution, the first structure of a ... |
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Increased glutamine in leaves of poplar transgenic with pine GS1a caused greater anthranilate synthetase α-subunit (ASA1) transcript and protein abundances: an auxin-related mechanism for enhanced growth in GS transgenics?
J. Exp. Bot. 62(13) , 4423-31, (2011) The initial reaction in the pathway leading to the production of indole-3-acetic acid (IAA) in plants is the reaction between chorismate and glutamine to produce anthranilate, catalysed by the enzyme anthranilate synthase (ASA; EC 4.1.3.27). Compared with non... |