ProcainaMide hydrochloride
ProcainaMide hydrochloride structure
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Common Name | ProcainaMide hydrochloride | ||
|---|---|---|---|---|
| CAS Number | 614-39-1 | Molecular Weight | 271.786 | |
| Density | N/A | Boiling Point | 421.8ºCat 760 mmHg | |
| Molecular Formula | C13H22ClN3O | Melting Point | 165-168 °C | |
| MSDS | Chinese USA | Flash Point | 208.9ºC | |
| Symbol |
GHS07 |
Signal Word | Warning | |
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Chemical genetics reveals a complex functional ground state of neural stem cells.
Nat. Chem. Biol. 3(5) , 268-273, (2007) The identification of self-renewing and multipotent neural stem cells (NSCs) in the mammalian brain holds promise for the treatment of neurological diseases and has yielded new insight into brain cancer. However, the complete repertoire of signaling pathways ... |
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Phase II metabolism in human skin: skin explants show full coverage for glucuronidation, sulfation, N-acetylation, catechol methylation, and glutathione conjugation.
Drug Metab. Dispos. 43(1) , 126-39, (2014) Although skin is the largest organ of the human body, cutaneous drug metabolism is often overlooked, and existing experimental models are insufficiently validated. This proof-of-concept study investigated phase II biotransformation of 11 test substrates in fr... |
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Thermal pretreatments of superficially porous silica particles for high-performance liquid chromatography: Surface control, structural characterization and chromatographic evaluation.
J. Chromatogr. A. 1419 , 45-57, (2015) This study reports the impact of thermal pretreatment between 400 and 1100°C on superficially porous silica particles (e.g. core-shell, fused-core; here abbreviated as SPP silica). The different thermally pretreated SPP silica (400°C, 900°C and 1100°C) were c... |
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Pharmacokinetic Modeling and Simulation of Procainamide andN-Acetylprocainamide in a Patient Receiving Continuous Renal Replacement Therapy: A Novel Approach to Guide Renal Dose Adjustments
Am. J. Kidney Dis. 61(6) , 1046-8, (2013)
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Assignment of Core versus Antenna Fucosylation Types in Protein N-Glycosylation via Procainamide Labeling and Tandem Mass Spectrometry.
Anal. Chem. 87 , 5905-13, (2015) Fucosylation is an important feature of protein N-glycosylation as it has been reported to influence the efficacy of therapeutic proteins and as a potential disease biomarker. A common approach for characterizing protein N-glycans is to analyze the native gly... |
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1-Aminobenzotriazole, a known cytochrome P450 inhibitor, is a substrate and inhibitor of N-acetyltransferase.
Drug Metab. Dispos. 39(9) , 1674-9, (2011) 1-Aminobenzotriazole (ABT) has been used widely as a nonselective in vitro and in vivo inhibitor of cytochrome P450 enzymes. To date, however, it has not been evaluated as an inhibitor of UDP-glucuronosyltransferase (UGT), sulfotransferase (SULT), and N-acety... |
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Wide complex tachycardia causing congestive heart failure.
Pacing Clin. Electrophysiol. 34(9) , 1154-7, (2011)
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Azithromycin kills invasive Aggregatibacter actinomycetemcomitans in gingival epithelial cells.
Antimicrob. Agents Chemother. 57(3) , 1347-51, (2013) Aggregatibacter actinomycetemcomitans invades periodontal pocket epithelium and is therefore difficult to eliminate by periodontal scaling and root planing. It is susceptible to azithromycin, which is taken up by many types of mammalian cells. This led us to ... |
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Does a Brugada pattern ECG precipitated by excessive-dose flecainide provide a diagnosis of a Brugada syndrome patient and/or contraindicate its use? A case study.
Circ. Arrhythm. Electrophysiol. 4(4) , e47-51, (2011)
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Use of procaine and procainamide as derivatizing co-matrices for the analysis of oligosaccharides by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry.
Rapid Commun. Mass Spectrom. 26(11) , 1311-9, (2012) Analysis of oligosaccharides by matrix-assisted laser desorption/ionization (MALDI) mass spectrometry often yields only alkali metal cation adducts, which results in lower fragmentation yields and difficulty to retrieve sequence information. Derivatization by... |