Bimatoprost
Bimatoprost structure
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Common Name | Bimatoprost | ||
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| CAS Number | 155206-00-1 | Molecular Weight | 415.566 | |
| Density | 1.1±0.1 g/cm3 | Boiling Point | 629.8±55.0 °C at 760 mmHg | |
| Molecular Formula | C25H37NO4 | Melting Point | 66-68°C | |
| MSDS | USA | Flash Point | 334.7±31.5 °C | |
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A retrospective review and observational study of outcomes and safety of bimatoprost ophthalmic solution 0.03% for treating eyelash hypotrichosis.
Dermatol. Surg. 40(10) , 1118-24, (2014) The efficacy and safety of bimatoprost ophthalmic solution 0.03% for treating hypotrichosis were shown in a randomized controlled trial and in an open-label study. To date, no data on real-world experience have been published.To evaluate long-term patient sat... |
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Conjunctiva-associated lymphoid tissue (CALT) reactions to antiglaucoma prostaglandins with or without BAK-preservative in rabbit acute toxicity study.
PLoS ONE 7 , e33913, (2012) Conjunctiva-associated lymphoid tissue (CALT) is closely associated with ocular surface immunity. This study investigated the effects of antiglaucoma prostaglandin analogs with or without benzalkonium chloride (BAK) preservative on organized CALT using an acu... |
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Expression profile of inflammatory cytokines in aqueous from glaucomatous eyes.
Mol. Vis. 18 , 431-8, (2012) To determine the proinflammatory cytokine profile of aqueous humor from glaucomatous eyes.Aqueous humor samples were prospectively collected from 38 eyes (26 primary open angle glaucoma [POAG] and 12 primary angle closure glaucoma [PACG] eyes) of 37 medically... |
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Toxicological evaluation of preservative-containing and preservative-free topical prostaglandin analogues on a three-dimensional-reconstituted corneal epithelium system.
Br. J. Ophthalmol. 95 , 869-75, (2011) Using an established three-dimensional (3D) toxicological model based on reconstituted human corneal epithelium (HCE), this study investigated the tolerability of four topical intraocular-pressure-lowering agents: the commercial solutions of benzalkonium chlo... |
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Comparison of the ocular tolerability of a latanoprost cationic emulsion versus conventional formulations of prostaglandins: an in vivo toxicity assay.
Mol. Vis. 15 , 1690-9, (2009) Using an established rabbit toxicological model, this in vivo study compared the ocular cytotoxicity of four topical intraocular pressure (IOP)-lowering agents: the commercial benzalkonium chloride (BAC)-containing solutions of 0.005% latanoprost, 0.004% trav... |
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Impact of the introduction of generic latanoprost on glaucoma medication adherence.
Ophthalmology 122(4) , 738-47, (2015) To assess possible changes in medication adherence to prostaglandin analog (PGA) regimens among patients with open-angle glaucoma (OAG) after the initial introduction of generic PGAs.Longitudinal cohort analysis.Patients older than 40 years with OAG continuou... |
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Identification and pharmacological characterization of the prostaglandin FP receptor and FP receptor variant complexes.
Br. J. Pharmacol. 154 , 1079-93, (2008) A prostamide analogue, bimatoprost, has been shown to be effective in reducing intraocular pressure, but its precise mechanism of action remains unclear. Hence, to elucidate the molecular mechanisms of this effect of bimatoprost, we focused on pharmacological... |
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Effects of Four Formulations of Prostaglandin Analogs on Eye Surface Cells. A Comparative Study.
PLoS ONE 10 , e0129419, (2015) We evaluated the cytotoxic effects of four prostaglandin analogs (PGAs) used to treat glaucoma. First we established primary cultures of conjunctival stromal cells from healthy donors. Then cell cultures were incubated with different concentrations (0, 0.1, 1... |
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Effect of glaucoma medications on 24-hour intraocular pressure-related patterns using a contact lens sensor.
Clin. Experiment. Ophthalmol. 43 , 787-95, (2015) The aim of this article was to study the circadian intraocular pressure (IOP)-related effects of ocular hypotensive medications using a contact lens sensor (CLS).This is a university-based prospective, randomized, crossover trial.A total of 23 patients with p... |
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Bimatoprost versus Mometasone Furoate in the Treatment of Scalp Alopecia Areata: A Pilot Study.
Dermatology 230 , 308-13, (2015) Alopecia areata (AA) is an immune-mediated disease that targets anagen hair follicles. Despite various therapeutic options, there is no cure for AA. Prostaglandin analogues have been recognized as being capable of inducing hypertrichosis.To compare the effica... |