Trichlormethine (hydrochloride)
Trichlormethine (hydrochloride) structure
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Common Name | Trichlormethine (hydrochloride) | ||
|---|---|---|---|---|
| CAS Number | 817-09-4 | Molecular Weight | 240.98600 | |
| Density | N/A | Boiling Point | 156.2ºC at 760 mmHg | |
| Molecular Formula | C6H13Cl4N | Melting Point | 127-130ºC(lit.) | |
| MSDS | Chinese USA | Flash Point | 48.3ºC | |
| Symbol |
GHS05, GHS06, GHS08 |
Signal Word | Danger | |
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Identification of the nitrogen-based blister agents bis(2-chloroethyl)methylamine (HN-2) and tris(2-chloroethyl)amine (HN-3) and their hydrolysis products on soil using ion trap secondary ion mass spectrometry.
J. Mass Spectrom. 35(12) , 1460-9, (2000) The nitrogen blister agents HN-2 (bis(2-chloroethyl)methylamine) and HN-3 (tris(2-chloroethyl)amine) were directly analyzed on the surface of soil samples using ion trap secondary ion mass spectrometry (SIMS). In the presence of water, HN-1 (bis(2-choroethyl)... |
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Ameliorative effect of DRDE 07 and its analogues on the systemic toxicity of sulphur mustard and nitrogen mustard in rabbit.
Hum. Exp. Toxicol. 29(9) , 747-55, (2010) Despite extensive research efforts, there is no unanimous approval of any animal model to evaluate the toxicity of sulphur mustard [SM; bis (2-chloroethyl) sulphide] or nitrogen mustard [HN-3; tris-(2-chloroethyl) amine] and screening of various prophylactic ... |
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Carcinogenicity of trichloromethine hydrochloride (TS-160 Spofa) and morphological damage after its intraamniotic injection.
Neoplasma 28(5) , 565-74, (1981) The cytostatic TS-160 (trichloromethine hydrochloride, tris-/2-chloroethyl/amine hydrochloride) was injected subcutaneously into SPF Wistar rats of both sexes. After all doses used, spindle-cell or even polymorphocellular sarcomas developes at the injection s... |
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Treatment of advanced Hodgkin's disease with modified MOPP regimens. A long-term observation.
Neoplasma 36(6) , 709-18, (1989) Fifty-three patients with advanced Hodgkin's disease, most of them previously treated, received 8 to 16 courses of modified MOPP regimens (nitrogen mustard replaced by trichlormethine in arm A, with addition of vinblastine to the 4-drug regimen in arm B, and ... |
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The effects of radiation and alkylating agents on chromatin degradation in normal and tumour lymphoid cells.
Gen. Physiol. Biophys. 10(1) , 41-8, (1991) The dynamic of chromatin degradation was studied in thymocytes and LS/BL tumour cells. In permeabilised LS/BL cells, the rate of DNA degradation induced by endogenous calcium and magnesium-dependent endonuclease was approx. 25 times slower than in thymocytes.... |
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Landmark article Sept. 21, 1946: Nitrogen mustard therapy. Use of methyl-bis(beta-chloroethyl)amine hydrochloride and tris(beta-chloroethyl)amine hydrochloride for Hodgkin's disease, lymphosarcoma, leukemia and certain allied and miscellaneous disorders. By Louis S. Goodman, Maxwell M. Wintrobe, William Dameshek, Morton J. Goodman, Alfred Gilman and Margaret T. McLennan.
JAMA 251(17) , 2255-61, (1984)
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Trichloromethyl ketones as synthetically versatile donors: application in direct catalytic mannich-type reactions and the stereoselective synthesis of azetidines.
Angew. Chem. Int. Ed. Engl. 45(19) , 3146-50, (2006)
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Heterogeneity of tumor cells.
Antibiot. Chemother. 28 , 120-2, (1980) Investigations of cell clones isolated in vitro, or selected in vivo, have shown that tumor cell populations are heterogenous. The isolated cell clones or cell subpopulations originating from a single tumor may differ in a variety of biological and biochemica... |
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Trichlormethine (trimustine hydrochloride).
IARC Monogr. Eval. Carcinog. Risks Hum. 50 , 143-9, (1990)
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[The effect of irradiation and alkylating agents on chromatin breakdown in normal and malignant lymphoid cells].
Radiobiologiia 31(1) , 22-6, (1991) Regularities of chromatin degradation in thymocytes and LS/BL tumor cells have been investigated. It has been shown that the rate of DNA degradation by Ca/Mg-dependent endonuclease in LS/BL tumor cells is 25 times lower than that in thymocytes, and radiation ... |