4-Bromophenylboronic Acid
4-Bromophenylboronic Acid structure
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Common Name | 4-Bromophenylboronic Acid | ||
|---|---|---|---|---|
| CAS Number | 5467-74-3 | Molecular Weight | 200.826 | |
| Density | 1.7±0.1 g/cm3 | Boiling Point | 315.0±44.0 °C at 760 mmHg | |
| Molecular Formula | C6H6BBrO2 | Melting Point | 284-288 °C(lit.) | |
| MSDS | Chinese USA | Flash Point | 144.3±28.4 °C | |
| Symbol |
GHS07 |
Signal Word | Warning | |
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Immobilised lipase for in vitro lipolysis experiments.
J. Pharm. Sci. 104(4) , 1311-8, (2015) In vitro lipolysis experiments are used to assess digestion of lipid-based formulations, and probe solubilisation by colloidal phases during digestion. However, proteins and other biological components in the pancreatin often used as the lipase result in high... |
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Understanding the Mechanism of Enzyme-Induced Formation of Lyotropic Liquid Crystalline Nanoparticles.
Langmuir 31 , 6933-41, (2015) Liquid crystalline nanoparticles have shown great potential for application in fields of drug delivery and agriculture. However, optimized approaches to generating these dispersions have long been sought after. This study focused on understanding the mechanis... |
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Non-linear increases in danazol exposure with dose in older vs. younger beagle dogs: the potential role of differences in bile salt concentration, thermodynamic activity, and formulation digestion.
Pharm. Res. 31(6) , 1536-52, (2014) To explore the possibility that age-related changes in physiology may result in differences in drug bioavailability after oral administration of lipid based formulations of danazol.Danazol absorption from lipid formulations with increasing drug load was exami... |
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In vitro and in vivo evaluations of the performance of an indirubin derivative, formulated in four different self-emulsifying drug delivery systems.
J. Pharm. Pharmacol. 66(11) , 1567-75, (2014) Anticancer indirubins are poorly soluble in water. Here, digestion of four self-emulsifying drug delivery systems (SEDDS) containing E804 (indirubin-3'-oxime 2,3-dihydroxypropyl ether) was compared by dynamic lipolysis and bioavailability studies. Used lipids... |
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An in vitro digestion test that reflects rat intestinal conditions to probe the importance of formulation digestion vs first pass metabolism in Danazol bioavailability from lipid based formulations.
Mol. Pharm. 11(11) , 4069-83, (2014) The impact of gastrointestinal (GI) processing and first pass metabolism on danazol oral bioavailability (BA) was evaluated after administration of self-emulsifying drug delivery systems (SEDDS) in the rat. Danazol absolute BA was determined following oral an... |
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Toward the establishment of standardized in vitro tests for lipid-based formulations, part 4: proposing a new lipid formulation performance classification system.
J. Pharm. Sci. 103(8) , 2441-55, (2014) The Lipid Formulation Classification System Consortium looks to develop standardized in vitro tests and to generate much-needed performance criteria for lipid-based formulations (LBFs). This article highlights the value of performing a second, more stressful ... |
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'Stealth' lipid-based formulations: poly(ethylene glycol)-mediated digestion inhibition improves oral bioavailability of a model poorly water soluble drug.
J. Control. Release 192 , 219-27, (2014) For over 20years, stealth drug delivery has been synonymous with nanoparticulate formulations and intravenous dosing. The putative determinants of stealth in these applications are the molecular weight and packing density of a hydrophilic polymer (commonly po... |
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Nanostructured lipid carriers versus microemulsions for delivery of the poorly water-soluble drug luteolin.
Int. J. Pharm. 476(1-2) , 169-77, (2015) Nanostructured lipid carriers and microemulsions effectively deliver poorly water-soluble drugs. However, few studies have investigated their ability and difference in improving drug bioavailability, especially the factors contributed to the difference. Thus,... |
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Effect of lipolysis on drug release from self-microemulsifying drug delivery systems (SMEDDS) with different core/shell drug location.
AAPS PharmSciTech 15(3) , 731-40, (2014) The objective of this study is to investigate the effect of lipolysis on the release of poorly water-soluble drug from SMEDDS in the perspective of drug core/shell location. For this purpose, four SMEDDS formulations with various core/shell properties were de... |
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Carbonic anhydrase inhibitors. Inhibition of the fungal beta-carbonic anhydrases from Candida albicans and Cryptococcus neoformans with boronic acids.
Bioorg. Med. Chem. Lett. 19 , 2642-5, (2009) Inhibition of the beta-carbonic anhydrases (CAs, EC 4.2.1.1) from the pathogenic fungi Cryptococcus neoformans (Can2) and Candida albicans (Nce103) with a series of aromatic, arylalkenyl- and arylalkylboronic acids was investigated. Aromatic, 4-phenylsubstitu... |