ecgonin hcl
ecgonin hcl structure
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Common Name | ecgonin hcl | ||
|---|---|---|---|---|
| CAS Number | 5796-31-6 | Molecular Weight | 221.68100 | |
| Density | N/A | Boiling Point | 376.3ºC at 760 mmHg | |
| Molecular Formula | C9H16ClNO3 | Melting Point | 246° | |
| MSDS | N/A | Flash Point | 181.4ºC | |
| Symbol |
GHS02, GHS06, GHS08 |
Signal Word | Danger | |
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Urinary excretion of ecgonine and five other cocaine metabolites following controlled oral, intravenous, intranasal, and smoked administration of cocaine.
J. Anal. Toxicol. 34(2) , 57-63, (2010) Urinary excretion of ecgonine (EC) was compared to that of cocaine, benzoylecgonine, ecgonine methyl ester and minor metabolites, meta-hydroxybenzoylecgonine, para-hydroxybenzoylecgonine, and norbenzoylecgonine, following controlled administration of oral, in... |
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Application of discriminant analysis to differentiate between incorporation of cocaine and its congeners into hair and contamination.
Forensic Sci. Int. 176(1) , 13-8, (2008) The requirement to differentiate between incorporation and external contamination of drugs into hair is undisputed, in particular when dealing with compounds which are administered by sniffing or inhalation (e.g. cocaine). With the aim of making this discrimi... |
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Determination of the highest no-effect dose (HNED) and of the elimination pattern for cocaine in horses.
J. Appl. Toxicol. 22(2) , 117-21, (2002) Cocaine is one of the most widespread illegal stimulants utilized by the human population throughout the world. The aim of this study was to establish the highest no-effect dose (HNED) of cocaine on the spontaneous locomotor activity (SLA) of horses in a beha... |
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Analysis of ecgonine and other cocaine biotransformation products in postmortem whole blood by protein precipitation-extractive alkylation and GC-MS.
J. Anal. Toxicol. 20(6) , 463-7, (1996) Ecgonine is formed by the hydrolysis of both ester linkages in cocaine and is of interest as both a potential metabolite and a postmortem and postcollection artifact in biological specimens. Its extreme polarity and water solubility make its isolation very di... |
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An automated SPE/LC/MS/MS method for the analysis of cocaine and metabolites in whole blood.
J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 874(1-2) , 15-20, (2008) As laboratories are called upon to develop novel, fast, and sensitive methods, here we present a completely automated method for the analysis of cocaine and its metabolites (benzoylecgonine, ecgonine methyl ester, ecgonine and cocaethylene) from whole blood. ... |
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Gender differences in cocaine pharmacokinetics in CF-1 mice.
Toxicol. Lett. 155(1) , 35-40, (2005) Hepatocellular damage is thought to occur as a result of cytochrome P450-mediated oxidation of cocaine to norcocaine (NC), a precursor of the hepatotoxic nitrosonium ion. However, this damage occurs only in male mice, with females exhibiting minimal biochemic... |
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In vitro stability of cocaine in whole blood and plasma including ecgonine as a target analyte.
Ther. Drug Monit. 23(2) , 174-81, (2001) The in vitro stability of cocaine (COC) was monitored in fresh whole blood and plasma stabilized with potassium fluoride (0.25%) for as long as 15 days. The samples were stored at 4 degreesC, 20 degreesC and 40 degreesC. Additionally, fresh plasma samples con... |
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Degradation of cocaine by a mixed culture of Pseudomonas fluorescens MBER and Comamonas acidovorans MBLF.
Appl. Environ. Microbiol. 62(1) , 94-9, (1996) A mixed culture that could utilize cocaine as the sole source of carbon and energy for growth was isolated by selective enrichment. The individual microorganisms within this mixed culture were identified as Pseudomonas fluorescens (termed MBER) and Comamonas ... |
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The application of supercritical fluid extraction to cocaine and its metabolites in blood and urine.
J. Anal. Toxicol. 24(3) , 228-32, (2000) Supercritical fluid extraction (SFE) is emerging as a valuable analytical technique for use as an alternative to conventional solid-phase (SPE) and liquid-liquid extraction techniques. It is a relatively new technique based on the use of supercritical fluids ... |
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The effect of cocaine and its metabolites on Sertoli cell function.
J. Urol. 155(1) , 163-6, (1996) We determined the in vitro effects of cocaine and its 2 major metabolites, benzoylecgonine and ecgonine, on Sertoli cell function.Sertoli cells were isolated from 18 to 20-day-old Sprague-Dawley rats. Sertoli cells were incubated with 4 concentrations (6.25 x... |