ecgonine methyl ester
ecgonine methyl ester structure
|
Common Name | ecgonine methyl ester | ||
|---|---|---|---|---|
| CAS Number | 7143-09-1 | Molecular Weight | 199.24700 | |
| Density | 1.181g/cm3 | Boiling Point | 305.8ºC at 760 mmHg | |
| Molecular Formula | C10H17NO3 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 138.7ºC | |
| Symbol |
GHS02, GHS07 |
Signal Word | Danger | |
|
Urinary excretion of ecgonine and five other cocaine metabolites following controlled oral, intravenous, intranasal, and smoked administration of cocaine.
J. Anal. Toxicol. 34(2) , 57-63, (2010) Urinary excretion of ecgonine (EC) was compared to that of cocaine, benzoylecgonine, ecgonine methyl ester and minor metabolites, meta-hydroxybenzoylecgonine, para-hydroxybenzoylecgonine, and norbenzoylecgonine, following controlled administration of oral, in... |
|
|
Analysis of cocaine and three of its metabolites in hair by gas chromatography-mass spectrometry using ion-trap detection for CI/MS/MS.
J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 826(1-2) , 17-25, (2005) A sensitive GC/CI/MS/MS method was developed for the simultaneous determination of cocaine (COC), anhydroecgonine methylester (cocaine pyrolysis product, AEME), ecgonine methylester (cocaine enzymatic hydrolysis product, EME) and cocaethylene (cocaine with et... |
|
|
Simple method for determination of cocaine and main metabolites in urine by CE coupled to MS.
Electrophoresis 30(12) , 2238-44, (2009) In this work, a simple method for the simultaneous determination of cocaine (COC) and five COC metabolites (benzoylecgonine, cocaethylene (CET), anhydroecgonine, anhydroecgonine methyl ester and ecgonine methyl ester) in human urine using CE coupled to MS via... |
|
|
Development and validation of a solid-phase extraction gas chromatography-mass spectrometry method for the simultaneous quantification of methadone, heroin, cocaine and metabolites in sweat.
Anal. Bioanal. Chem 392(1-2) , 115-27, (2008) A sensitive and specific method is presented to simultaneously quantify methadone, heroin, cocaine and metabolites in sweat. Drugs were eluted from sweat patches with sodium acetate buffer, followed by SPE and quantification by GC/MS with electron impact ioni... |
|
|
Application of discriminant analysis to differentiate between incorporation of cocaine and its congeners into hair and contamination.
Forensic Sci. Int. 176(1) , 13-8, (2008) The requirement to differentiate between incorporation and external contamination of drugs into hair is undisputed, in particular when dealing with compounds which are administered by sniffing or inhalation (e.g. cocaine). With the aim of making this discrimi... |
|
|
Estrogen and progesterone affect cocaine pharmacokinetics in female rats.
Brain Res. Bull. 68(5) , 310-4, (2006) Several studies have reported sex differences in behavioral responses to cocaine whereby females display a greater degree of locomotor activity. Fluctuations in estrogen and progesterone during the estrous cycle have been postulated to underlie these behavior... |
|
|
Biotransformation kinetics and sorption of cocaine and its metabolites and the factors influencing their estimation in wastewater.
Water Res. 47(7) , 2129-40, (2013) The quantitative analysis of human urinary metabolites as biomarkers in wastewater streams has been used to estimate the rates of illicit drug use in the wider community. The primary underlying assumption in such studies is that a sample of wastewater is equi... |
|
|
Adolescents are more vulnerable to cocaine addiction: behavioral and electrophysiological evidence.
J. Neurosci. 33(11) , 4913-22, (2013) In humans, adolescence is a period of heightened propensity to develop cocaine addiction. It is unknown whether this is attributable to greater access and exposure to cocaine at this age, or whether the adolescent brain is particularly vulnerable to the addic... |
|
|
A self-microemulsifying drug delivery system to overcome intestinal resveratrol toxicity and presystemic metabolism.
Anal. Chim. Acta 772 , 40-6, (2013) A mixed lipid-mixed surfactant self-microemulsifying drug delivery system (SMEDDS) was developed to exploit the health benefits of resveratrol, a Biopharmaceutical Classification System Class 2 natural polyphenol, subject to extensive intestinal presystemic m... |
|
|
Transformation of cocaine during water chlorination.
Anal. Bioanal. Chem 404(10) , 3135-44, (2012) The stability of cocaine and its two main human metabolites, benzoylecgonine and ecgonine methyl ester, in chlorine-containing waters has been investigated by direct injection of different reaction time aliquots in a liquid chromatograph (LC) coupled to a qua... |