Hydrocodone
Hydrocodone structure
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Common Name | Hydrocodone | ||
|---|---|---|---|---|
| CAS Number | 125-29-1 | Molecular Weight | 299.364 | |
| Density | 1.3±0.1 g/cm3 | Boiling Point | 461.4±45.0 °C at 760 mmHg | |
| Molecular Formula | C18H21NO3 | Melting Point | 198ºC | |
| MSDS | N/A | Flash Point | 232.9±28.7 °C | |
| Symbol |
GHS07, GHS08, GHS09 |
Signal Word | Danger | |
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Pharmacokinetic evaluation of hydrocodone/acetaminophen for pain management.
J. Opioid Manag. 9(1) , 71-80, (2013) Hydrocodone/acetaminophen is not only the most commonly prescribed opioid in the United States but also the most common prescription medication written in America. Although original and early trials confirmed its ability to manage acute pain from surgery and ... |
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Opioid prescribing patterns after Mohs micrographic surgery and standard excision: a survey of American Society for Dermatologic Surgery members and a chart review at a single institution.
Dermatol. Surg. 40(8) , 906-11, (2014) Little is known about postoperative opioid prescribing patterns among dermatologic surgeons.To better understand postoperative opioid prescribing patterns among dermatologic surgeons in the United States.Two-part analysis consisting of a retrospective chart r... |
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Validation of a computer case definition for sudden cardiac death in opioid users.
BMC Res. Notes 5 , 473, (2012) To facilitate the use of automated databases for studies of sudden cardiac death, we previously developed a computerized case definition that had a positive predictive value between 86% and 88%. However, the definition has not been specifically validated for ... |
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Narcotic prescribing habits and other methods of pain control by oral and maxillofacial surgeons after impacted third molar removal.
J. Oral Maxillofac. Surg. 71(9) , 1500-3, (2013) It has been suggested that a source of narcotics used for nonmedical purposes by young adults is the unused opioids prescribed for the management of pain after the removal of impacted third molars. The purpose of the present study was to determine whether ora... |
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Evaluation of a single-dose, extended-release epidural morphine formulation for pain control after lumbar spine surgery.
J. Surg. Orthop. Adv. 23(1) , 9-12, (2014) DepoDur, an extended-release epidural morphine, has been used effectively for postoperative pain control following many orthopaedic and general surgery procedures and has provided prolonged analgesia when compared with Duramorph. The goal of this article was ... |
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Clinical characteristics of cough mixture abusers referred to three substance abuse clinics in Hong Kong: a retrospective study.
East Asian Arch. Psychiatry 22(4) , 154-9, (2012) OBJECTIVES. Cough mixture is the third most commonly abused substance in patients attending the Prince of Wales Hospital Substance Abuse Clinic. The content of the local cough mixture is not well researched. Paranoid psychosis manifesting as persecutory delus... |
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Excretion profile of hydrocodone, hydromorphone and norhydrocodone in urine following single dose administration of hydrocodone to healthy volunteers.
J. Anal. Toxicol. 36(7) , 507-14, (2012) Abuse of prescription opioids for non-medical use has been on the rise over the past decade. The most commonly abused opioid is hydrocodone, a frequently prescribed pain medication metabolized by the body to hydromorphone, norhydrocodone and other minor metab... |
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Relationship between the concentration of hydrocodone and its conversion to hydromorphone in chronic pain patients using urinary excretion data.
J. Anal. Toxicol. 36(4) , 257-64, (2012) Hydrocodone in combination with acetaminophen is commonly used to control moderate pain and is metabolized by cytochrome P4502D6 to form the active metabolite, hydromorphone. The purpose of this study was to determine the metabolic relationship and variabilit... |
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In vivo activity of norhydrocodone: an active metabolite of hydrocodone.
J. Pharmacol. Exp. Ther. 347(2) , 497-505, (2013) Hydrocodone is primarily metabolized to hydromorphone and norhydrocodone. Although hydromorphone is a known active metabolite of hydrocodone, the in vivo activity of norhydrocodone is not well documented. In the current study, the pharmacodynamics of norhydro... |
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Quantitative method for analysis of hydrocodone, hydromorphone and norhydrocodone in human plasma by liquid chromatography-tandem mass spectrometry.
J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 925 , 40-5, (2013) A selective, sensitive and accurate high-performance liquid chromatography-tandem mass spectrometry (LC-MS-MS) method for the quantitation of hydrocodone, hydromorphone and norhydrocodone in human plasma was developed. The internal standard stock solution com... |