Dihydromorphine
Dihydromorphine structure
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Common Name | Dihydromorphine | ||
|---|---|---|---|---|
| CAS Number | 509-60-4 | Molecular Weight | 287.35400 | |
| Density | 1.4 g/cm3 | Boiling Point | 475.4ºC at 760 mmHg | |
| Molecular Formula | C17H21NO3 | Melting Point | > 275ºC | |
| MSDS | N/A | Flash Point | 241.3ºC | |
| Symbol |
GHS02, GHS06, GHS08 |
Signal Word | Danger | |
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Hydromorphone metabolites: isolation and identification from pooled urine samples of a cancer patient.
Xenobiotica 32(5) , 427-39, (2002) 1. Hydromorphone-3-glucuronide, dihydromorphine, dihydroisomorphine, dihydromorphine-3-glucuronide and dihydroisomorphine-3-glucuronide were isolated from a cancer patient's urine and identified as metabolites of hydromorphone by comparison with synthetic sta... |
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Nociceptin, endomorphin-1 and -2 do not interact with invertebrate immune and neural mu 3 opiate receptor.
Acta Pharmacol. Sin. 21(6) , 516-20, (2000) To determine if endomorphin-1, -2 and nociceptin (orphanin FQ) bind to the mu 3 opiate receptor subtype or release nitric oxide as mu 3 selective ligands do.These opioid peptides were examined for their ability to displace [3H]dihydromorphine (DHM) binding fr... |
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Bradykinin antagonists in human systems: correlation between receptor binding, calcium signalling in isolated cells, and functional activity in isolated ileum.
Biochem. Pharmacol. 54(2) , 283-91, (1997) The determination of the relationship between ligand affinity and bioactivity is important for the understanding of receptor function in biological systems and for drug development. Several physiological and pathophysiological functions of bradykinin (BK) are... |
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Thermodynamic parameters of opioid binding in the presence and absence of G-protein coupling.
J. Recept. Signal Transduct. Res. 16(3-4) , 151-68, (1996) We have investigated the thermodynamic parameters of various opioid ligands interacting with their receptors in rat brain membranes. Affinity constants (Ka), enthalpy and entropy values were obtained from homologous displacement experiments performed at 0, 24... |
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The detection of dihydrocodeine and its main metabolites in cases of fatal overdose.
Int. J. Legal Med. 112(3) , 155-8, (1999) The levels of dihydrocodeine found in impaired individuals and in fatalities show a wide overlap in the ranges. Among other factors, the genetically controlled metabolism of dihydrocodeine should play an important role in dihydrocodeine toxicity. For the firs... |
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Practical and high-yield syntheses of dihydromorphine from tetrahydrothebaine and efficient syntheses of (8S)-8-bromomorphide.
J. Org. Chem. 68(5) , 2010-3, (2003) A practical method for the conversion of tetrahydrothebaine to dihydromorphine in 92% yield is described. The procedure should allow more efficient production of opium products and may be easily modified for large-scale synthesis. The conversion of codeine to... |
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Morphine-related metabolites differentially activate adenylyl cyclase isozymes after acute and chronic administration.
FEBS Lett. 470(3) , 309-14, (2000) Morphine-3- and morphine-6-glucuronide are morphine's major metabolites. As morphine-6-glucuronide produces stronger analgesia than morphine, we investigated the effects of acute and chronic morphine glucuronides on adenylyl cyclase (AC) activity. Using COS-7... |
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Opiate receptor binding properties of morphine-, dihydromorphine-, and codeine 6-O-sulfate ester congeners.
Bioorg. Med. Chem. Lett. 16(16) , 4291-5, (2006) A series of 3-O-acyl-6-O-sulfate esters of morphine, dihydromorphine, N-methylmorphinium iodide, codeine, and dihydrocodeine were prepared and evaluated for their ability to bind to mu-, delta-, kappa(1)-, kappa(2)-, and kappa(3)-opiate receptors. Several com... |
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Pharmacological characterization of dihydromorphine, 6-acetyldihydromorphine and dihydroheroin analgesia and their differentiation from morphine.
Eur. J. Pharmacol. 492(2-3) , 123-30, (2004) The present study examined the pharmacology of dihydromorphine, 6-acetyldihydromorphine and dihydroheroin (3,6-diacetyldihydromorphine). Like morphine, dihydromorphine and its acetylated derivatives all were highly selective mu-opioids in receptor binding ass... |
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Analgesia and serum assays of controlled-release dihydrocodeine and metabolites in cancer patients with pain
Pharmacol. Rep. 64(1) , 84-93, (2012) Abstract Aim of the study was to assess dihydrocodeine (DHC) and metabolites concentrations and their correlations with DHC analgesia in cancer patients with pain. Thirty opioid-naive patients with nociceptive pain intensity assessed by VAS (visual analogue s... |