4,4'-Dithiodipyridine
4,4'-Dithiodipyridine structure
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Common Name | 4,4'-Dithiodipyridine | ||
|---|---|---|---|---|
| CAS Number | 2645-22-9 | Molecular Weight | 220.31400 | |
| Density | 1.34 g/cm3 | Boiling Point | 356.1ºC at 760 mmHg | |
| Molecular Formula | C10H8N2S2 | Melting Point | 76-78 °C(lit.) | |
| MSDS | Chinese USA | Flash Point | 169.2ºC | |
| Symbol |
GHS07 |
Signal Word | Warning | |
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Oxidative stress and lipid peroxidation are upstream of amyloid pathology.
Neurobiol. Dis. 84 , 109-19, (2015) Oxidative stress is a common feature of the aging process and of many neurodegenerative disorders, including Alzheimer's disease. Understanding the direct causative relationship between oxidative stress and amyloid pathology, and determining the underlying mo... |
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Molecularly imprinted tunable binding sites based on conjugated prosthetic groups and ion-paired cofactors.
J. Am. Chem. Soc. 131(25) , 8833-8, (2009) A molecular imprinting technique was applied to the construction of prosthetic group-coupled tunable binding cavities for bisphenol A (BPA). A novel template molecule, with a structure consisting of BPA covalently conjugated with two allyl(4-carboxyphenyl)dis... |
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Quick measurement of protein sulfhydryls with Ellman's reagent and with 4,4'-dithiodipyridine.
Anal. Bioanal. Chem 373(4-5) , 266-76, (2002) Since its introduction in 1959, Ellman's reagent (5,5'-dithio-bis(2-nitrobenzoic acid)) has been the favorite reagent for spectrophotometric measurement of protein sulfhydryls. Meanwhile however, evidence has accumulated that many protein sulfhydryls give an ... |
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Sulfhydryl modification by 4,4'-dithiodipyridine induces calcium mobilization in human osteoblast-like cells.
Arch. Toxicol. 77(11) , 630-7, (2003) The effect of oxidants on Ca(2+) movement in osteoblasts is unclear. In this study, we show that 4,4'-dithiodipyridine (4,4'-DTDP), a reactive disulphide that mobilizes Ca(2+) in muscle, induces an increase in cytoplasmic free-Ca(2+) concentrations ([Ca(2+)](... |
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O6-alkylguanine-DNA alkyltransferase: low pKa and high reactivity of cysteine 145.
Biochemistry 42(37) , 10965-70, (2003) The active site cysteine of human O(6)-alkylguanine-DNA alkyltransferase (hAGT), Cys145, was shown to be highly reactive with model electrophiles unrelated to substrates, including 1-chloro-2,4-dinitrobenzene. The high reactivity suggested that the Cys145 thi... |
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Biphasic modulation of ryanodine receptors by sulfhydryl oxidation in rat ventricular myocytes.
Biophys. J. 91(8) , 2882-91, (2006) To understand better the modulation of ryanodine receptors (RyRs) during oxidative stress, the effect of 4,4'-dithiodipyridine (DTDP), a cell-permeant and thiol-reactive oxidant, on global Ca(2+) signal and spontaneous Ca(2+) sparks of rat ventricular myocyte... |
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Cytoplasmic glutathione redox status determines survival upon exposure to the thiol-oxidant 4,4'-dipyridyl disulfide.
FEMS Yeast Res. 7(3) , 391-403, (2007) Dipyridyl disulfide (DPS) is a highly reactive thiol oxidant that functions as electron acceptor in thiol-disulfide exchange reactions. DPS is very toxic to yeasts, impairing growth at low micromolar concentrations. The genes TRX2 (thioredoxin), SOD1 (superox... |
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Conformational change of the E-F interhelical loop in the M photointermediate of bacteriorhodopsin.
J. Mol. Biol. 317(3) , 471-8, (2002) The conformation of the structured EF interhelical loop of bacteriorhodopsin and its change in the M photointermediate were assessed by measuring the rate of reaction of 16 single engineered cysteine residues along the loop with water-soluble sulfhydryl reage... |
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Synthesis and structural characterization of binuclear half-sandwich iridium, rhodium and ruthenium complexes containing 4,4'-dipyridyldisulfide (4DPDS) ligands.
Dalton Trans. 39(30) , 7119-24, (2010) Reactions of half-sandwich iridium and rhodium complexes [Cp*MCl2]2 (1a: M = Ir, 1b: M = Rh) and the half-sandwich ruthenium complex [(p-cymene)RuCl2]2 (1c) with 4DPDS gave the corresponding binuclear complexes [{Cp*MCl2]2}(m-4DPDS) (2a: M = Ir, 2b: M = Rh) a... |
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Oxidant resistance in a yeast mutant deficient in the Sit4 phosphatase.
Curr. Genet. 53(5) , 275-86, (2008) Resistance to thiol oxidation can arise from mutations altering redox homeostasis. A Saccharomyces cerevisiae sit4-110 mutant is here described, which was isolated as resistant to the thiol-specific oxidant dipyridyl disulfide (DPS) and which contains a singl... |