H-Phe(4-I)-OH
H-Phe(4-I)-OH structure
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Common Name | H-Phe(4-I)-OH | ||
|---|---|---|---|---|
| CAS Number | 24250-85-9 | Molecular Weight | 291.086 | |
| Density | 1.8±0.1 g/cm3 | Boiling Point | 366.8±32.0 °C at 760 mmHg | |
| Molecular Formula | C9H10INO2 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 175.6±25.1 °C | |
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A nonradioactive approach to investigate the metabolism of therapeutic peptides by tagging with 127i and using inductively-coupled plasma mass spectrometry analysis.
Drug Metab. Dispos. 43(1) , 17-26, (2014) The metabolic fate of adrenocorticotropic hormone (ACTH) fragment 4-10 (4-10) was evaluated following incorporation of a nonradioactive (127)I-tag and with selective detection of I(+) at m/z 127 by inductively coupled plasma mass spectrometry (ICP-MS). (127)I... |
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An expanded eukaryotic genetic code.
Science 301(5635) , 964-7, (2003) We describe a general and rapid route for the addition of unnatural amino acids to the genetic code of Saccharomyces cerevisiae. Five amino acids have been incorporated into proteins efficiently and with high fidelity in response to the nonsense codon TAG. Th... |
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p-[123I]iodo-L-phenylalanine for detection of pancreatic cancer: basic investigations of the uptake characteristics in primary human pancreatic tumour cells and evaluation in in vivo models of human pancreatic adenocarcinoma.
Eur. J. Nucl. Med. Mol. Imaging 31(4) , 532-41, (2004) Pancreatic cancer is associated with the worst 5-year survival rate of any human cancer. This high mortality is due, in part, to difficulties in establishing early and accurate diagnosis. Because most tumours share the ability to accumulate amino acids more e... |
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Validation of brain tumour imaging with p-[123I]iodo-L-phenylalanine and SPECT.
Eur. J. Nucl. Med. Mol. Imaging 32(9) , 1041-9, (2005) The aims of this prospective study were to validate single-photon emission computed tomography (SPECT) with p-[(123)I]iodo-L-phenylalanine (IPA) in brain tumours and to evaluate its potential for the characterisation of indeterminate brain lesions.In 45 patie... |
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One plasmid selection system for the rapid evolution of aminoacyl-tRNA synthetases.
Bioorg. Med. Chem. Lett. 19 , 3845-3847, (2009) We have developed a rapid, straightforward, one plasmid dual positive/negative selection system for the evolution of aminoacyl-tRNA synthetases with altered specificities in Escherichia coli. This system utilizes an amber stop codon containing chloramphenicol... |
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Initial evaluation of the feasibility of single photon emission tomography with p-[123 I]iodo-L-phenylalanine for routine brain tumour imaging.
Nucl. Med. Commun. 23(2) , 121-30, (2002) p-[123I]iodo-L-phenylalanine (IPA) is a recently described radiopharmaceutical which is highly accumulated in gliomas. The present investigation was designed to evaluate the feasibility of single photon emission tomography (SPET) with IPA to image brain tumou... |
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Synthesis of peptide labelled with p-iodophenylalanine which corresponds to the first amphipathic region of apolipoprotein C-I.
Int. J. Pept. Protein Res. 26(2) , 208-13, (1985) The amino terminal fragment (1-15) of apolipoprotein C-1, H-Thr-Pro-Asp-Val-Ser-Ser-Ala-Leu-Asp-Lys-Leu-Lys-Glu-Phe14-Gly was prepared by the solid phase method. However, the phenylalanine residue at position 14 was replaced with p-iodophenylalanine in the ch... |
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Differentiation of enantiomeric drugs by iodo-substituted L-amino acid references under electrospray ionization mass spectrometric conditions.
Rapid Commun. Mass Spectrom. 26(11) , 1385-91, (2012) In chiral differentiation by mass spectrometry, use of a single reference that differentiates various classes of compounds including drugs is ideal, but so far there are no such reports in the literature. We have successfully used iodo-substituted amino acids... |
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Para-[(123)I]iodo-L-phenylalanine in patients with pancreatic adenocarcinoma: tumour uptake, whole-body kinetics, dosimetry.
Nuklearmedizin. 47(5) , 220-4, (2008) Recently, p-[(123)I]iodo-L-phenylalanine (IPA) was clinically validated for brain tumour imaging. Preclinical studies demonstrated uptake of IPA into pancreatic adenocarcinoma suggesting its diagnostic application in patients with pancreatic tumours. The aim ... |
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An alternative and expedient synthesis of radioiodinated 4-iodophenylalanine.
Appl. Radiat. Isot. 69(10) , 1401-6, (2011) Radiolabeled amino acids have been used extensively in oncology both as diagnostic and therapeutic agents. In our pursuit to develop radiopharmaceuticals to target breast cancer, we were interested in determining the uptake of radioiodinated 4-iodophenylalani... |