3,4-Dichloro-isocoumarin

3,4-Dichloro-isocoumarin Structure
3,4-Dichloro-isocoumarin structure
Common Name 3,4-Dichloro-isocoumarin
CAS Number 51050-59-0 Molecular Weight 215.03300
Density 1.53 g/cm3 Boiling Point 304.7ºC at 760 mmHg
Molecular Formula C9H4Cl2O2 Melting Point N/A
MSDS Chinese USA Flash Point 136.6ºC
Symbol GHS06
GHS06
Signal Word Danger

Regulatory T cells require TCR signaling for their suppressive function.

J. Immunol. 194 , 4362-70, (2015)

Regulatory T cells (Tregs) are a subset of CD4(+) T cells that maintain immune tolerance in part by their ability to inhibit the proliferation of conventional CD4(+) T cells (Tconvs). The role of the TCR and the downstream signaling pathways required for this...

Chemical genetics reveals a complex functional ground state of neural stem cells.

Nat. Chem. Biol. 3(5) , 268-273, (2007)

The identification of self-renewing and multipotent neural stem cells (NSCs) in the mammalian brain holds promise for the treatment of neurological diseases and has yielded new insight into brain cancer. However, the complete repertoire of signaling pathways ...

Polarized granzyme release is required for antigen-driven transendothelial migration of human effector memory CD4 T cells.

J. Immunol. 193(12) , 5809-15, (2014)

Human effector memory CD4 T cells may transmigrate across endothelial cell (EC) monolayers either in response to inflammatory chemokines or in response to TCR recognition of Ag presented on the surface of the EC. The kinetics, morphologic manifestations, and ...

Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum.

Nat. Chem. Biol. 5 , 765-71, (2009)

Studies of gene function and molecular mechanisms in Plasmodium falciparum are hampered by difficulties in characterizing and measuring phenotypic differences between individual parasites. We screened seven parasite lines for differences in responses to 1,279...

SUMO deconjugation is required for arsenic-triggered ubiquitylation of PML.

Sci. Signal. 8 , ra56, (2015)

Acute promyelocytic leukemia is characterized by a chromosomal translocation that produces an oncogenic fusion protein of the retinoic acid receptor α (RARα) and promyelocytic leukemia protein (PML). Arsenic trioxide chemotherapy of this cancer induces the PM...

Features of cell death, mitochondrial activation and caspase dependence of rabbit anti-T-lymphocyte globulin signaling in lymphoblastic Jurkat cells are distinct from classical apoptosis signaling of CD95.

Leuk. Lymphoma 57 , 177-82, (2016)

Rabbit anti-T-lymphocyte-globulin (ATG) is used for immunosuppression in organ and stem cell transplantation. The aim of this study was to investigate ATG-induced cell death compared to CD95-signaling of apoptosis. We measured features of cell death at the ce...

Protective and pathological functions of CD8+ T cells in Leishmania braziliensis infection.

Infect. Immun. 83(3) , 898-906, (2015)

Cutaneous leishmaniasis (CL) caused by Leishmania braziliensis is characterized by a strong Th1 response that leads to skin lesion development. In areas where L. braziliensis transmission is endemic, up to 15% of healthy subjects have tested positive for dela...

Identification of a potent, selective, and orally active leukotriene a4 hydrolase inhibitor with anti-inflammatory activity.

J. Med. Chem. 51 , 4150-69, (2008)

LTA 4H is a ubiquitously distributed 69 kDa zinc-containing cytosolic enzyme with both hydrolase and aminopeptidase activity. As a hydrolase, LTA 4H stereospecifically catalyzes the transformation of the unstable epoxide LTA 4 to the diol LTB 4, a potent chem...

Granule exocytosis mediates immune surveillance of senescent cells.

Oncogene 32(15) , 1971-7, (2013)

Senescence is a stable cell cycle arrest program that contributes to tumor suppression, organismal aging and certain wound healing responses. During liver fibrosis, for example, hepatic stellate cells initially proliferate and secrete extracellular matrix com...

Isolation and characterization of bovine thymus multicatalytic proteinase complex.

Protein Expr. Purif. 18(2) , 160-8, (2000)

The multicatalytic proteinase complex (MPC or proteasome) from bovine thymus was isolated and purified to homogeneity applying a protocol utilizing ion exchange and gel permeation chromatography as major purification tools. The purified complex shows molecula...