Molsidomine
Molsidomine structure
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Common Name | Molsidomine | ||
|---|---|---|---|---|
| CAS Number | 25717-80-0 | Molecular Weight | 242.232 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C9H14N4O4 | Melting Point | 140-141°C | |
| MSDS | Chinese USA | Flash Point | N/A | |
| Symbol |
GHS07 |
Signal Word | Warning | |
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Taurine reduces nitrosative stress and nitric oxide synthase expression in high glucose-exposed human Schwann cells.
Exp. Neurol. 233(1) , 154-62, (2012) The role of taurine in regulating glucose-induced nitrosative stress has been examined in human Schwann cells, a model for understanding the pathogenesis of diabetic neuropathy. Exposure to high glucose increased nitrated proteins (1.56 fold p<0.05), inducibl... |
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Comparative kinetics of thiol oxidation in two distinct free-radical generating systems: SIN-1 versus AAPH.
Free Radic. Res. 46(10) , 1190-200, (2012) To study oxidative stress in biological systems, chemical compounds capable of producing free radicals have been widely used. Here, we compared two free-radical generators, 3-morpholinosydnonimine (SIN-1) and 2,2'-azo-bis(2-amidinopropane) hydrochloride (AAPH... |
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Conformational altered p53 as an early marker of oxidative stress in Alzheimer's disease.
PLoS ONE 7(1) , e29789, (2012) In order to study oxidative stress in peripheral cells of Alzheimer's disease (AD) patients, immortalized lymphocytes derived from two peculiar cohorts of patients, referring to early onset AD (EOSAD) and subjects harboured AD related mutation (ADmut), were u... |
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Angiostatin production increases in response to decreased nitric oxide in aging rat kidney.
Lab. Invest. 93(3) , 334-43, (2013) The development of interstitial fibrosis occurs with aging. Impaired angiogenesis, associated with progressive loss of the renal microvasculature, is thought to be a cause of age-related nephropathy. However, the mechanism of capillary loss in aging kidney ha... |
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Sauchinone blocks methamphetamine-induced hyperlocomotion and place preference in mice.
Phytomedicine 20(12) , 1071-5, (2013) Sauchinone is a phytochemical known as a nitric oxide (NO) inhibitor. NO is a kind of neurotransmitter and involved in psychotic effect of abuse drug. In present, we carried out a study on the effect of sauchinone on methamphetamine-induced alteration of beha... |
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Peroxynitrite donor SIN-1 alters high-affinity choline transporter activity by modifying its intracellular trafficking.
J. Neurosci. 32(16) , 5573-84, (2012) Sodium-coupled, high-affinity choline transporters (CHTs) are inhibited by 3-morpholinosydnonimine (SIN-1) [peroxynitrite (ONOO⁻) donor]; ONOO⁻ can be produced from nitric oxide and reactive oxygen species during neurodegeneration. SIN-1 rapidly increases CHT... |
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Response of mitochondrial antioxidant system and respiratory pathways to reactive nitrogen species in pea leaves.
Physiol. Plant. 147(2) , 194-206, (2013) Nitric oxide (NO) has emerged as an important signaling molecule in plants, but little is known about the effects of reactive nitrogen species in plant mitochondria. In this study, the effects of DETA-NONOate, a pure NO slow generator, and of SIN-1 (3-morphol... |
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Topical combinations to treat microvascular dysfunction of chronic postischemia pain.
Anesth. Analg. 118(4) , 830-40, (2014) Growing evidence indicates that patients with complex regional pain syndrome (CRPS) exhibit tissue abnormalities caused by microvascular dysfunction in the blood vessels of skin, muscle, and nerve. We tested whether topical combinations aimed at improving mic... |
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Cardiovascular pharmacology of molsidomine.
Bibl. Cardiol. (38) , 234-43, (1984)
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[Molsidomine in the treatment of ischemic heart disease].
Wiad. Lek. 40(20) , 1389-95, (1987)
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