Mianserin hydrochloride
Mianserin hydrochloride structure
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Common Name | Mianserin hydrochloride | ||
|---|---|---|---|---|
| CAS Number | 21535-47-7 | Molecular Weight | 300.826 | |
| Density | 1.18 g/cm3 | Boiling Point | 411.3ºC at 760 mmHg | |
| Molecular Formula | C18H21ClN2 | Melting Point | >230ºC (dec.) | |
| MSDS | Chinese USA | Flash Point | 186.1ºC | |
| Symbol |
GHS07 |
Signal Word | Warning | |
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Hook proteins: association with Alzheimer pathology and regulatory role of hook3 in amyloid beta generation.
PLoS ONE 10(3) , e0119423, (2015) Defects in intracellular transport are implicated in the pathogenesis of Alzheimer's disease (AD). Hook proteins are a family of cytoplasmic linker proteins that participate in endosomal transport. In this study we show that Hook1 and Hook3 are expressed in n... |
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Kuwanon V inhibits proliferation, promotes cell survival and increases neurogenesis of neural stem cells.
PLoS ONE 10(2) , e0118188, (2015) Neural stem cells (NSCs) have the ability to proliferate and differentiate into neurons and glia. Regulation of NSC fate by small molecules is important for the generation of a certain type of cell. The identification of small molecules that can induce new ne... |
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Antidepressants activate the lysophosphatidic acid receptor LPA(1) to induce insulin-like growth factor-I receptor transactivation, stimulation of ERK1/2 signaling and cell proliferation in CHO-K1 fibroblasts.
Biochem. Pharmacol. 95 , 311-23, (2015) Different lines of evidence indicate that the lysophosphatidic acid (LPA) receptor LPA1 is involved in neurogenesis, synaptic plasticity and anxiety-related behavior, but little is known on whether this receptor can be targeted by neuropsychopharmacological a... |
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Chemical genetics reveals a complex functional ground state of neural stem cells.
Nat. Chem. Biol. 3(5) , 268-273, (2007) The identification of self-renewing and multipotent neural stem cells (NSCs) in the mammalian brain holds promise for the treatment of neurological diseases and has yielded new insight into brain cancer. However, the complete repertoire of signaling pathways ... |
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Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum.
Nat. Chem. Biol. 5 , 765-71, (2009) Studies of gene function and molecular mechanisms in Plasmodium falciparum are hampered by difficulties in characterizing and measuring phenotypic differences between individual parasites. We screened seven parasite lines for differences in responses to 1,279... |
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Gingival pain: an unusual side effect of ziprasidone.
BMJ Case Rep. 2013 , doi:10.1136/bcr-2012-007577, (2013) The patient is a 52-year-old man with schizophrenia who developed severe, unremitting gingival pain after his ziprasidone dosage was increased from 80 to 120 mg. His physical examination and laboratory findings were unremarkable. He did not have any extra-pyr... |
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Microfluidic gradients reveal enhanced neurite outgrowth but impaired guidance within 3D matrices with high integrin ligand densities.
Small 11(6) , 722-30, (2015) The density of integrin-binding ligands in an extracellular matrix (ECM) is known to regulate cell migration speed by imposing a balance of traction forces between the leading and trailing edges of the cell, but the effect of cell-adhesive ligands on neurite ... |
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S100 alone has the same destructive effect on retinal ganglion cells as in combination with HSP 27 in an autoimmune glaucoma model.
J. Mol. Neurosci. 56(1) , 228-36, (2015) As previously shown, immunization with ocular antigens, like heat shock protein 27 (HSP 27), leads to retinal ganglion cell loss in an autoimmune glaucoma model. Aim of this study was to assess how immunization with S100 alone and in combination with HSP 27 a... |
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Immune quiescence of the brain is set by astroglial connexin 43.
J. Neurosci. 35(10) , 4427-39, (2015) In the normal brain, immune cell trafficking and immune responses are strictly controlled and limited. This unique homeostatic equilibrium, also called brain immune quiescence, is crucial to maintaining proper brain functions and is altered in various patholo... |
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Generation of new neurons in dorsal root Ganglia in adult rats after peripheral nerve crush injury.
Neural Plast. 2015 , 860546, (2015) The evidence of neurons generated ex novo in sensory ganglia of adult animals is still debated. In the present study, we investigated, using high resolution light microscopy and stereological analysis, the changes in the number of neurons in dorsal root gangl... |