Benzyl chloroformate
Benzyl chloroformate structure
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Common Name | Benzyl chloroformate | ||
|---|---|---|---|---|
| CAS Number | 501-53-1 | Molecular Weight | 170.593 | |
| Density | 1.2±0.1 g/cm3 | Boiling Point | 224.0±19.0 °C at 760 mmHg | |
| Molecular Formula | C8H7ClO2 | Melting Point | -20 °C | |
| MSDS | Chinese USA | Flash Point | 73.5±13.6 °C | |
| Symbol |
GHS05, GHS07, GHS08, GHS09 |
Signal Word | Danger | |
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Polymeric micelles for pH-responsive delivery of cisplatin.
J. Drug Target. 22(7) , 629-37, (2014) Methoxy poly(ethylene oxide)-block-poly-(α-carboxylate-ε-caprolactone) (PEO-b-PCCL) was used to develop pH-responsive polymeric micelles for the delivery of cisplatin (CDDP). Micelles were prepared through complexation of CDDP with the pendant carboxyl groups... |
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Ames Salmonella/mammalian-microsome testing of peptides and peptide synthesis reagents.
Mutat. Res. 170(1-2) , 23-9, (1986) The Ames Salmonella/mammalian-microsome assay was used to evaluate the bacterial mutagenicity of 6 bioactive peptides and of 11 chemical reagents used in peptide synthesis. Samples of 2 reagents, bis(2-oxo-3-oxazolidinyl)phosphinic chloride and fluoren-9-ylme... |
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Untargeted metabolomics in doping control: detection of new markers of testosterone misuse by ultrahigh performance liquid chromatography coupled to high-resolution mass spectrometry.
Anal. Chem. 87 , 8373-80, (2015) The use of untargeted metabolomics for the discovery of markers is a promising and virtually unexplored tool in the doping control field. Hybrid quadrupole time-of-flight (QTOF) and hybrid quadrupole Orbitrap (Q Exactive) mass spectrometers, coupled to ultrah... |
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Curtius rearrangement of aromatic carboxylic acids to access protected anilines and aromatic ureas.
Org. Lett. 8 , 5717, (2006) The reaction of a chloroformate or di-tert-butyl dicarbonate and sodium azide with an aromatic carboxylic acid produces the corresponding acyl azide, presumably through the formation of an azidoformate. The acyl azide undergoes a Curtius rearrangement to form... |
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Synthesis, colon-targeted studies and pharmacological evaluation of an anti-ulcerative colitis drug 4-Aminosalicylic acid-β-O-glucoside.
Eur. J. Med. Chem. 108 , 486-94, (2016) A glycoside prodrug of 4-aminosalicylic acid (4-ASA) with d-glucose was synthesized for targeted drug delivery to inflammatory bowel. The in vitro assessment of 4-aminosalicylic acid-β-O-glucoside (4-ASA-Glu) as a colon-specific prodrug was studied using coli... |
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Controlled release kinetics of p-aminosalicylic acid from biodegradable crosslinked polyesters for enhanced anti-mycobacterial activity.
Acta Biomater. 30 , 168-76, (2015) Unlike conventional polymeric drug delivery systems, where drugs are entrapped in polymers, this study focuses on the incorporation of the drug into the polymer backbone to achieve higher loading and sustained release. Crosslinked, biodegradable, xylitol base... |
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Highly sensitive determination of chlorpheniramine as fluorescence derivative by high-performance liquid chromatography.
J. Chromatogr. A. 420(1) , 63-72, (1987) A new method has been developed for the quantitative analysis of chlorpheniramine in human blood using high-performance liquid chromatography with a fluorescence detector. Benzyl chloroformate was found to be suitable as a fluorometric derivatizing reagent. A... |
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The beta-bend ribbon spiral. Synthesis and conformational analysis in solution and in the crystal state of depsipeptides containing alpha-hydroxyisobutyric acid.
Int. J. Pept. Protein Res. 41(6) , 553-60, (1993) The synthesis and conformational analysis in solution (by FTIR absorption and 1H NMR) and in the crystal state (by X-ray diffraction) of three Hib-containing depsipeptides have been performed. In the crystal state Z-Aib-Hib-Aib-OMe is folded into a type-III b... |
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An improved synthesis of a trifurcated newkome-type monomer and orthogonally protected two-generation dendrons.
J. Org. Chem. 67(4) , 1411-3, (2002) The one-step synthesis of amino-polyether tri-tert-butyl ester monomer 2, by condensation of TRIS with tert-butyl acrylate, is reported. The nitrogen of the monomer can be protected with a Cbz group; subsequent removal of the tert-butyl esters with formic aci... |
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High yield regioselective monobenzyloxycarbonylation of secondary alcohols in glycopyranoside series.
Carbohydr. Res. 338(22) , 2409-12, (2003) The regioselective monobenzyloxycarbonylation of secondary alcohols in methyl 6-O-(4-methoxytrityl)-alpha-D-manno-, gluco- and galactopyranoside has been achieved in high yields (74-85%) by using benzyl chloroformate in the presence of 4-dimethylaminopyridine... |