N-Methylguanosine
N-Methylguanosine structure
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Common Name | N-Methylguanosine | ||
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| CAS Number | 2140-77-4 | Molecular Weight | 297.267 | |
| Density | 2.0±0.1 g/cm3 | Boiling Point | 709.5ºC at 760mmHg | |
| Molecular Formula | C11H15N5O5 | Melting Point | 233 °C (decomp)(Solv: water (7732-18-5)) | |
| MSDS | Chinese USA | Flash Point | 382.9ºC | |
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Exometabolom analysis of breast cancer cell lines: Metabolic signature.
Sci. Rep. 5 , 13374, (2015) Cancer cells show characteristic effects on cellular turnover and DNA/RNA modifications leading to elevated levels of excreted modified nucleosides. We investigated the molecular signature of different subtypes of breast cancer cell lines and the breast epith... |
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Artificial receptors for the extraction of nucleoside metabolite 7-methylguanosine from aqueous media made by molecular imprinting.
J. Chromatogr. A. 1365 , 12-8, (2014) A series of imprinted polymers targeting nucleoside metabolites, prepared using a template analogue approach, are presented. These were prepared following selection of the optimum functional monomer by solution association studies using (1)H NMR titrations wh... |
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Functional screen reveals SARS coronavirus nonstructural protein nsp14 as a novel cap N7 methyltransferase.
Proc. Natl. Acad. Sci. U. S. A. 106 , 3484-3489, (2009) The N7-methylguanosine (m7G) cap is the defining structural feature of eukaryotic mRNAs. Most eukaryotic viruses that replicate in the cytoplasm, including coronaviruses, have evolved strategies to cap their RNAs. In this report, we used a yeast genetic syste... |
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Cap-binding complex (CBC).
Biochem. J. 457(2) , 231-42, (2014) The 7mG (7-methylguanosine cap) formed on mRNA is fundamental to eukaryotic gene expression. Protein complexes recruited to 7mG mediate key processing events throughout the lifetime of the transcript. One of the most important mediators of 7mG functions is CB... |
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Identification of a quality-control mechanism for mRNA 5'-end capping.
Nature 467(7315) , 608-11, (2010) The 7-methylguanosine cap structure at the 5' end of eukaryotic messenger RNAs is a critical determinant of their stability and translational efficiency. It is generally believed that 5'-end capping is a constitutive process that occurs during mRNA maturation... |
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Trimethylguanosine capping selectively promotes expression of Rev-dependent HIV-1 RNAs.
Proc. Natl. Acad. Sci. U. S. A. 107(33) , 14787-92, (2010) 5'-mRNA capping is an early modification that affects pre-mRNA synthesis/splicing, RNA cytoplasmic transport, and mRNA translation and turnover. In eukaryotes, a 7-methylguanosine (m7G) cap is added to newly transcribed RNA polymerase II (RNAP II) transcripts... |
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Synthesis and characterization of mRNA cap analogs containing phosphorothioate substitutions that bind tightly to eIF4E and are resistant to the decapping pyrophosphatase DcpS.
RNA 14(6) , 1119-31, (2008) Analogs of the mRNA cap are widely employed to study processes involved in mRNA metabolism as well as being useful in biotechnology and medicinal applications. Here we describe synthesis of six dinucleotide cap analogs bearing a single phosphorothioate modifi... |
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Pumilio 2 controls translation by competing with eIF4E for 7-methyl guanosine cap recognition.
RNA 16(1) , 221-7, (2010) Pumilio 2 (Pum2) interacts with the 3' UTR-containing pumilio binding element (PBE) of RINGO/SPY mRNA to repress translation in Xenopus oocytes. Here, we show that Pum2 also binds directly to the 5' 7mG cap structure; in so doing, it precludes eIF4E from bind... |
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Regulation of mRNA cap methylation.
Biochem. J. 425(2) , 295-302, (2010) The 7-methylguanosine cap added to the 5' end of mRNA is essential for efficient gene expression and cell viability. Methylation of the guanosine cap is necessary for the translation of most cellular mRNAs in all eukaryotic organisms in which it has been inve... |
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RAM/Fam103a1 is required for mRNA cap methylation.
Mol. Cell. 44(4) , 585-96, (2011) The 7-methylguanosine cap added to the 5' end of mRNA is required for efficient gene expression in eukaryotes. In mammals, methylation of the guanosine cap is catalyzed by RNMT (RNA guanine-7 methyltransferase), an enzyme previously thought to function as a m... |