Floxuridine
Floxuridine structure
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Common Name | Floxuridine | ||
|---|---|---|---|---|
| CAS Number | 50-91-9 | Molecular Weight | 246.192 | |
| Density | 1.8±0.1 g/cm3 | Boiling Point | 483.0±55.0 °C at 760 mmHg | |
| Molecular Formula | C9H11FN2O5 | Melting Point | 148 °C(lit.) | |
| MSDS | Chinese USA | Flash Point | 245.9±31.5 °C | |
| Symbol |
GHS06 |
Signal Word | Danger | |
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Synthesis and Characterization of New 1,2,4-Triazolo[1,5-a]pyridines That Extend the Life Span of Caenorhabiditis elegans via Their Anti-Inflammatory/Antioxidant Effects.
Arch. Pharm. (Weinheim) 348 , 650-65, (2015) In the present study, we describe the synthesis of a new set of 1,2,4-triazolo[1,5-a]pyridines and their fused ring systems. The products were assayed for various types of biological activities like anti-inflammatory and antioxidative activity. Compounds 4c, ... |
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KCNQ channels in nociceptive cold-sensing trigeminal ganglion neurons as therapeutic targets for treating orofacial cold hyperalgesia.
Mol. Pain 11 , 45, (2015) Hyperexcitability of nociceptive afferent fibers is an underlying mechanism of neuropathic pain and ion channels involved in neuronal excitability are potentially therapeutic targets. KCNQ channels, a subfamily of voltage-gated K(+) channels mediating M-curre... |
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Transcriptional expression of myelin basic protein in oligodendrocytes depends on functional syntaxin 4: a potential correlation with autocrine signaling.
Mol. Cell. Biol. 35(4) , 675-87, (2015) Myelination of axons by oligodendrocytes is essential for saltatory nerve conduction. To form myelin membranes, a coordinated synthesis and subsequent polarized transport of myelin components are necessary. Here, we show that as part of the mechanism to estab... |
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Elimination of formate production in Clostridium thermocellum.
J. Ind. Microbiol. Biotechnol. 42 , 1263-72, (2015) The ability of Clostridium thermocellum to rapidly degrade cellulose and ferment resulting hydrolysis products into ethanol makes it a promising platform organism for cellulosic biofuel production via consolidated bioprocessing. Currently, however, ethanol yi... |
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Lifespan extension and increased resistance to environmental stressors by N-acetyl-L-cysteine in Caenorhabditis elegans.
Clinics (Sao. Paulo.) 70 , 380-6, (2015) This study was performed to determine the effect of N-acetyl-L-cysteine, a modified sulfur-containing amino acid that acts as a strong cellular antioxidant, on the response to environmental stressors and on aging in C. elegans.The survival of worms under oxid... |
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Intrinsic innate immunity fails to control herpes simplex virus and vesicular stomatitis virus replication in sensory neurons and fibroblasts.
J. Virol. 88(17) , 9991-10001, (2014) Herpes simplex virus 1 (HSV-1) establishes lifelong latent infections in the sensory neurons of the trigeminal ganglia (TG), wherein it retains the capacity to reactivate. The interferon (IFN)-driven antiviral response is critical for the control of HSV-1 acu... |
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Developmental abnormality induced by strong static magnetic field in Caenorhabditis elegans.
Bioelectromagnetics 36(3) , 178-89, (2015) Understanding the effects of strong static magnetic fields (SMFs) on living organisms is significant in health risk assessment, but underlying mechanisms are largely unknown. In the present study, we determined developmental abnormalities induced by 8.5Tesla ... |
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Reproductive Toxicity of Endosulfan: Implication From Germ Cell Apoptosis Modulated by Mitochondrial Dysfunction and Genotoxic Response Genes in Caenorhabditis elegans.
Toxicol. Sci. 145 , 118-27, (2015) Endosulfan as a new member of persistent organic pollutants has been shown to induce reproductive dysfunction in various animal models. However, the action mechanism of endosulfan-produced reproductive toxicity remains largely unknown. This study was focused ... |
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Isolation, structure determination, and antiaging effects of 2,3-pentanediol from endophytic fungus of Curcuma amada and docking studies.
Protoplasma 251(5) , 1089-98, (2014) An endophytic fungus was isolated from the rhizomes of Curcuma amada (Zingiberaceae), which was identified as Fusarium oxysporum on the basis of its morphological and molecular characters. Chromatographic separation and spectroscopic analysis of the fungal me... |
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Suppression of transcriptional drift extends C. elegans lifespan by postponing the onset of mortality.
Elife 4 , (2015) Longevity mechanisms increase lifespan by counteracting the effects of aging. However, whether longevity mechanisms counteract the effects of aging continually throughout life, or whether they act during specific periods of life, preventing changes that prece... |