Diosmin
Diosmin structure
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Common Name | Diosmin | ||
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| CAS Number | 520-27-4 | Molecular Weight | 608.545 | |
| Density | 1.7±0.1 g/cm3 | Boiling Point | 926.8±65.0 °C at 760 mmHg | |
| Molecular Formula | C28H32O15 | Melting Point | 277-278°C | |
| MSDS | Chinese USA | Flash Point | 305.2±27.8 °C | |
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Diosmin induces genotoxicity and apoptosis in DU145 prostate cancer cell line.
Toxicol. In Vitro 29(3) , 417-25, (2015) Plant-derived dietary polyphenolic compounds, such as flavonoids, with cancer cell-specific pro-apoptotic activity and chemopreventive potential are thought to be promising anticancer agents. In the present study, we were interested in determining if flavonoi... |
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Amino acid, mineral, and polyphenolic profiles of black vinegar, and its lipid lowering and antioxidant effects in vivo.
Food Chem. 168 , 63-9, (2014) Black vinegar (BV) contains abundant essential and hydrophobic amino acids, and polyphenolic contents, especially catechin and chlorogenic acid via chemical analyses. K and Mg are the major minerals in BV, and Ca, Fe, Mn, and Se are also measured. After a 9-w... |
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Flavonoids are inhibitors of human organic anion transporter 1 (OAT1)-mediated transport.
Drug Metab. Dispos. 42(9) , 1357-66, (2014) Organic anion transporter 1 (OAT1) has been reported to be involved in the nephrotoxicity of many anionic xenobiotics. As current clinically used OAT1 inhibitors are often associated with safety issues, identifying potent OAT1 inhibitors with little toxicity ... |
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Development of novel polymer-stabilized diosmin nanosuspensions: in vitro appraisal and ex vivo permeation.
Int. J. Pharm. 454(1) , 462-71, (2013) Scanty solubility and permeability of diosmin (DSN) are perpetrators for its poor oral absorption and high inter-subject variation. This article investigated the potential of novel DSN nanosuspensions to improve drug delivery characteristics. Bottom-up nanopr... |
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Simultaneous quantification of 25 active constituents in the total flavonoids extract from Herba Desmodii Styracifolii by high-performance liquid chromatography with electrospray ionization tandem mass spectrometry.
J. Sep. Sci. 38(7) , 1156-63, (2015) A sensitive and selective high-performance liquid chromatography coupled with electrospray ionization tandem mass spectrometry method has been developed and validated for the simultaneous determination of 25 active constituents, including 21 flavonoids and fo... |
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Clinical effectiveness of a highly standardized and bioavailable mixture of flavonoids and triterpenes in the management of acute hemorroidal crisis.
Acta Biomed. 82(1) , 35-40, (2011) Patients with acute haemorrhoidal crisis often need of an immediate and effective pharmacological approach to alleviate their pain, bleeding and swelling or have to be referred by the general practitioner to the surgeon for a definitive treatment. Effective a... |
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Monograph. Diosmin.
Altern. Med. Rev. 9(3) , 308-11, (2004)
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[Hemorrhoids and conservative treatment. Review of the literature on the use of diosmin and micronized hesperidin].
Minerva Chir. 54(12) , 909-16, (1999)
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Enhancement of the water solubility of flavone glycosides by disruption of molecular planarity of the aglycone moiety.
J. Nat. Prod. 76(1) , 8-12, (2013) Enhancement of the water solubility by disruption of molecular planarity has recently been reviewed as a feasible approach in small-molecule drug discovery programs. We applied this strategy to some natural flavone glycosides, especially diosmin, a highly ins... |
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PP2A mediates diosmin p53 activation to block HA22T cell proliferation and tumor growth in xenografted nude mice through PI3K-Akt-MDM2 signaling suppression.
Food Chem. Toxicol. 50(5) , 1802-10, (2012) Hepatocellular carcinoma is a common type of cancer with poor prognosis. This study examines the in vitro and in vivo mechanisms of diosmin on human hepato-cellular carcinoma HA22T cell proliferation inhibition. HA22T cells were treated with different diosmin... |