7-Methoxyindole
7-Methoxyindole structure
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Common Name | 7-Methoxyindole | ||
|---|---|---|---|---|
| CAS Number | 3189-22-8 | Molecular Weight | 147.174 | |
| Density | 1.2±0.1 g/cm3 | Boiling Point | 297.8±13.0 °C at 760 mmHg | |
| Molecular Formula | C9H9NO | Melting Point | 147-150°C | |
| MSDS | Chinese USA | Flash Point | 109.2±10.1 °C | |
| Symbol |
GHS05, GHS07 |
Signal Word | Danger | |
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Tryptophan 2,3-dioxygenase (TDO) inhibitors. 3-(2-(pyridyl)ethenyl)indoles as potential anticancer immunomodulators.
J. Med. Chem. 54 , 5320, (2011) Tryptophan catabolism mediated by indoleamine 2,3-dioxygenase (IDO) is an important mechanism of peripheral immune tolerance contributing to tumoral immune resistance. IDO inhibition is thus an active area of research in drug development. Recently, our group ... |
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Identification of potent ITK inhibitors through focused compound library design including structural information
Bioorg. Med. Chem. Lett. 20 , 6998, (2010) A series of novel compound libraries inhibiting interleukin-2 inducible T cell kinase (ITK) were designed, synthesized and evaluated. In the first design cycle two library scaffolds were identified showing low micromolar inhibition of ITK. Further iterative d... |
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Utilization of indole analogs by carrot and tobacco cell tryptophan synthase in vivo and in vitro.
Plant Physiol. 67(6) , 1101-4, (1981) Twenty-three indole analogs were used to inhibit the growth of carrot and tobacco suspension cultures. The addition of tryptophan or indole partially reversed the inhibition of both cell lines only for 4-fluoroindole, 5-fluoroindole, and 6-fluoroindole. Inhib... |
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Meanwell, N., A.; et al.
Bioorg. Med. Chem. Lett. 20 , 1460, (2010)
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Trujillo, J., I.; et al.
Bioorg. Med. Chem. Lett. 19 , 2365, (2009)
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Exploring bis-(indolyl)methane moiety as an alternative and innovative CAP group in the design of histone deacetylase (HDAC) inhibitors.
Bioorg. Med. Chem. Lett. 19 , 2840, (2009) In order to gather further knowledge about the structural requirements on histone deacetylase inhibitors (HDACi), starting from the schematic model of the common pharmacophore that characterizes this class of molecules (surface recognition CAP group-connectio... |
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Molecular orbital calculations of magnetic circular dichroism spectra: a benzene-indole sequence.
Proc. Natl. Acad. Sci. U. S. A. 70(12) , 3754-8, (1973) The magnetic circular dichroism of benzene and indole derivatives was measured down to 190 nM. The following pairs of molecules have magnetic circular dichroisms of the opposite sign in the B(2u) absorption region: aniline and benzonitrile, indene and indolin... |