S-(2-Aminoethyl)pseudothiourea dihydrobromide

S-(2-Aminoethyl)pseudothiourea dihydrobromide Structure
S-(2-Aminoethyl)pseudothiourea dihydrobromide structure
Common Name S-(2-Aminoethyl)pseudothiourea dihydrobromide
CAS Number 56-10-0 Molecular Weight 281.013
Density N/A Boiling Point 231.1ºC at 760mmHg
Molecular Formula C3H11Br2N3S Melting Point 190-196 °C(lit.)
MSDS Chinese USA Flash Point 93.6ºC
Symbol GHS07
GHS07
Signal Word Warning

Chemical genetics reveals a complex functional ground state of neural stem cells.

Nat. Chem. Biol. 3(5) , 268-273, (2007)

The identification of self-renewing and multipotent neural stem cells (NSCs) in the mammalian brain holds promise for the treatment of neurological diseases and has yielded new insight into brain cancer. However, the complete repertoire of signaling pathways ...

Defects in mitochondrial efficiency and H2O2 emissions in obese women are restored to a lean phenotype with aerobic exercise training.

Diabetes 64 , 2104-15, (2015)

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Nucleic Acids Res. 43 , 3089-99, (2015)

Signal transduction ATPases with numerous domains (STAND) get activated through inducer-dependent assembly into multimeric platforms. This switch relies on the conversion of their nucleotide-binding oligomerization domain (NOD) from a closed, ADP-bound form t...

N(6)-(3-methoxyl-4-hydroxybenzyl) adenine riboside induces sedative and hypnotic effects via GAD enzyme activation in mice.

Pharmacol. Biochem. Behav. 126 , 146-51, (2014)

N(6)-(3-methoxyl-4-hydroxybenzyl) adenine riboside (B2) is an analog of N(6)-(4-hydroxybenzyl) adenine riboside (NHBA), which was originally isolated from Gastrodia elata Blume. Our laboratory has previously demonstrated that B2 can produce strong sedative an...

Differential activity of NO synthase inhibitors as chemopreventive agents in a primary rat tracheal epithelial cell transformation system.

Neoplasia 4(4) , 332-6, (2002)

A model to study the effectiveness of potential chemopreventive agents that inhibit neoplastic process by different mechanisms has been used to test the efficacy of seven nitric oxide synthase (NOS) inhibitors. Five selective inducible NOS (iNOS) inhibitors: ...

The effects of intracisternal enzyme replacement versus sham treatment on central neuropathology in preclinical canine fucosidosis.

Orphanet J. Rare Dis. 10 , 143, (2015)

Fucosidosis results from lack of α-L-fucosidase activity, with accumulation of fucose-linked substrates in the nervous system and viscera leading to progressive motor and mental deterioration, and death. The naturally occurring dog model of fucosidosis was us...

Certain S-substituted isothioureas not only inhibit NO synthase catalytic activity but also decrease translation and stability of inducible NO synthase protein.

Nitric Oxide 2(3) , 155-64, (1998)

In an attempt to identify potent inhibitors of inducible (type II) NO synthase (iNOS) for use in cell culture systems, we found that two S-substituted isothioureas were very potent in cell culture but one such compound also interfered with the induction of NO...

Pathophysiological role of nitric oxide in rat experimental colitis.

Int. J. Immunopharmacol. 19(11-12) , 669-76, (1997)

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Arh. Hig. Rada Toksikol. 60(2) , 129-38, (2009)

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Selective inhibition of inducible nitric oxide synthase maintains haemodynamic stability without untoward consequences for hepatic function or morphology.

Eur. J. Surg. 165(12) , 1167-74, (1999)

To examine the effects of the inducible nitric oxide synthase inhibitor aminoethyl-isothiourea (AE-ITU) on haemodynamic measurements, and correlate these with hepatic morphology and function in a porcine model of endotoxaemia.Experimental study.15 juvenile pi...