Mecobalamin
Mecobalamin structure
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Common Name | Mecobalamin | ||
|---|---|---|---|---|
| CAS Number | 13422-55-4 | Molecular Weight | 1344.382 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C63H91CoN13O14P | Melting Point | >190°C (dec.) | |
| MSDS | Chinese USA | Flash Point | N/A | |
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Environmental fate of the next generation refrigerant 2,3,3,3-tetrafluoropropene (HFO-1234yf).
Environ. Sci. Technol. 48(22) , 13181-7, (2014) The hydrofluoroolefin 2,3,3,3-tetrafluoropropene (HFO-1234yf) has been introduced to replace 1,1,1,2-tetrafluoroethane (HFC-134a) as refrigerant in mobile, including vehicle, air conditioning systems because of its lower global warming potential. HFO-1234yf i... |
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Thin-layer chromatography combined with diode laser thermal vaporization inductively coupled plasma mass spectrometry.
J. Chromatogr. A. 1364 , 271-5, (2014) Here we present a novel coupling of thin-layer chromatography (TLC) to diode laser thermal vaporization inductively coupled plasma mass spectrometry (DLTV ICP MS). DLTV is a new technique of aerosol generation which uses a diode laser to induce pyrolysis of a... |
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Processing of alkylcobalamins in mammalian cells: A role for the MMACHC (cblC) gene product.
Mol. Genet. Metab. 97 , 260-266, (2009) The MMACHC gene product of the cblC complementation group, referred to as the cblC protein, catalyzes the in vitro and in vivo decyanation of cyanocobalamin (vitamin B(12)). We hypothesized that the cblC protein would also catalyze the dealkylation of newly i... |
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Vitamin B12-derivatives-enzyme cofactors and ligands of proteins and nucleic acids.
Chem. Soc. Rev. 40 , 4346-4363, (2011) B(12)-cofactors play important roles in the metabolism of microorganisms, animals and humans. Microorganisms are the only natural sources of B(12)-derivatives, and the latter are "vitamins" for other B(12)-requiring organisms. Some B(12)-dependent enzymes cat... |
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B12 trafficking in mammals: A for coenzyme escort service.
ACS Chem. Biol. 1 , 149-159, (2006) Many coenzymes are vitamins that are assimilated in mammals into their active form from precursors obtained from the diet. They are often both rare and reactive rendering the likelihood low that the cell uses a collision-based strategy for their delivery to d... |
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A human vitamin B12 trafficking protein uses glutathione transferase activity for processing alkylcobalamins.
J. Biol. Chem. 284 , 33418-33424, (2009) Pathways for tailoring and processing vitamins into active cofactor forms exist in mammals that are unable to synthesize these cofactors de novo. A prerequisite for intracellular tailoring of alkylcobalamins entering from the circulation is removal of the alk... |
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Structural basis of multifunctionality in a vitamin B12-processing enzyme.
J. Biol. Chem. 286 , 29780-29787, (2011) An early step in the intracellular processing of vitamin B(12) involves CblC, which exhibits dual reactivity, catalyzing the reductive decyanation of cyanocobalamin (vitamin B(12)), and the dealkylation of alkylcobalamins (e.g. methylcobalamin; MeCbl). Insigh... |
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Adenosyltransferase: an enzyme and an escort for coenzyme B12?
Trends Biochem. Sci. 30 , 304-308, (2005) Many organic cofactors are both rare and reactive. They are usually in low abundance, which poses problems for efficient collision-based targeting to dependent enzymes, whereas their reactivity is problematic for side reactions. Sequestration and escorted del... |
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Methylcobalamin--a form of vitamin B12 identified and characterised in Chlorella vulgaris.
Food Chem. 170 , 316-20, (2014) Vitamin B12 is among the most essential biomolecules required for crucial metabolic processes in humans. Vitamin B12 was extracted from Chlorella vulgaris biomass under aqueous conditions, partially purified by passing the extract through amberlite XAD-2, Sep... |
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Connection between multimetal(loid) methylation in methanoarchaea and central intermediates of methanogenesis.
Appl. Environ. Microbiol. 77(24) , 8669-75, (2011) In spite of the significant impact of biomethylation on the mobility and toxicity of metals and metalloids in the environment, little is known about the biological formation of these methylated metal(loid) compounds. While element-specific methyltransferases ... |