Daurisoline
Daurisoline structure
|
Common Name | Daurisoline | ||
|---|---|---|---|---|
| CAS Number | 70553-76-3 | Molecular Weight | 610.739 | |
| Density | 1.2±0.1 g/cm3 | Boiling Point | 724.5±60.0 °C at 760 mmHg | |
| Molecular Formula | C37H42N2O6 | Melting Point | 96-102ºC | |
| MSDS | Chinese USA | Flash Point | 392.0±32.9 °C | |
|
Pharmacokinetic-pharmacodynamic modeling of daurisoline and dauricine in beagle dogs.
Acta Pharmacol. Sin. 24(10) , 1011-5, (2003) To study the combined pharmacokinetic-pharmacodynamic (PK-PD) model of daurisoline and dauricine, and compare their effects on cardiac electrophsiology, blood pressure, and hemodynamics in beagle dogs.The plasma drug concentration was determined by the revers... |
|
|
Effects of daurisoline on intracellular Ca2+ activity in myocardium.
Zhongguo Yao Li Xue Bao 17(3) , 248-51, (1996) To explain the effect of daurisoline (DS) on delayed afterdepolarization (DAD).Ca(2+)-sensitive microelectrode technic was used to record intracellular Ca2+ activity (alpha Cai) and triggered activity (TA) arising from DAD in myocardium.Strophantin G 3 mumol.... |
|
|
Effects of the putative P-type calcium channel blocker, R,R-(-)-daurisoline on neurotransmitter release.
Naunyn Schmiedebergs Arch. Pharmacol. 352(6) , 670-8, (1995) The alkaloid and medicinal herb constituent, R,R-(-)-daurisoline, was originally reported to be a N-type Ca2+ channel blocker, but newer evidence indicates that it is a blocker of P-type Ca2+ channels. To clarify its specificity with respect to N- and P-chann... |
|
|
Daurisoline derivatives inhibit the ability of calmodulin to stimulate cyclic nucleotide phosphodiesterase activity.
Cell. Signal. 2(4) , 353-7, (1990) Daurisoline alkaloid derivatives were found to be potent calmodulin (CaM) antagonists. The ability of daurisoline derivatives to attenuate the stimulatory effect on calmodulin activated cyclic nucleotides phosphodiesterase (CaM-PDE) was studied. These compoun... |
|
|
Effects of l-daurisoline on quinolinic acid-induced Ca2+ influx in hippocampus neurons in freely moving rats.
Zhongguo Yao Li Xue Bao 12(4) , 301-4, (1991) In freely moving rats, hippocampus neuronal extracellular calcium concentration (Ca2+)e and seizures were investigated. Application of quinolinic acid 156 nmol (exciting N-methyl-D-aspartate receptor, NMDA) to dorsal hippocampus elicited a decrease in (Ca2+)e... |
|
|
P-type calcium channels are blocked by the alkaloid daurisoline.
Neuroreport 5(12) , 1489-92, (1994) IN looking for a structurally defined non-peptide P-channel blocker we have tested the alkaloid daurisoline which has been isolated from traditional Chinese medicinal herb (Menispermum dauricum) used for the treatment of epilepsy, hypertension and asthma. We ... |
|
|
Effects of daurisoline on cytosolic free calcium in fetal rat cerebral cells.
Chin. Med. J. 108(4) , 265-8, (1995) Cytosolic free Ca2+ ([Ca2+]i) was measured in dissociated cerebral cells isolated from fetal rats with the fluorescent indicater fura-2. Increase in [Ca2+]i occurred rapidly following exposure of the cells to 50 mmol/L KCl, 10(-7) mol/L Bay K 8644 or 200 mumo... |
|
|
Studies on the interaction of daurisoline alkaloid derivatives and calmodulin by fluorescence spectroscopy.
Second Messengers Phosphoproteins 13(1) , 51-7, (1990) A new kind of bisbenzylisoquinoline compounds, daurisoline alkaloid derivatives, has been found to be very potent calmodulin antagonists. The fluorescence spectra of interaction between these derivatives and calmodulin have been studied. The experimental resu... |
|
|
l-S.R-daurisoline protects cultured hippocampal neurons against glutamate neurotoxicity by reducing nitric oxide production.
Zhongguo Yao Li Xue Bao 20(1) , 21-6, (1999) To explore mechanisms of l-S.R-daurisoline (DS)-mediated protection of cultured hippocampal neurons from sodium glutamate (Glu) cytotoxicity.Cultured neurons obtained from rat hippocampus were used to examine the protective effect of DS against Glu neurotoxic... |
|
|
[Antagonism of daurisoline on arrhythmogenic delayed afterdepolarization].
Yao Xue Xue Bao 29(9) , 647-51, (1994) Standard microelectrode technique was used to study the effect of daurisoline (DS) on delayed afterdepolarization (DAD) and triggered activity (TA) in guinea pig ventricular trabeculae. DS (50 mumol.L-1) abolished TA induced by ouabain or caffeine, inhibited ... |