Yao xue xue bao = Acta pharmaceutica Sinica 1994-01-01

[Antagonism of daurisoline on arrhythmogenic delayed afterdepolarization].

Z X Wang, J Q Zhu, F D Zeng, C J Hu

Index: Yao Xue Xue Bao 29(9) , 647-51, (1994)

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Abstract

Standard microelectrode technique was used to study the effect of daurisoline (DS) on delayed afterdepolarization (DAD) and triggered activity (TA) in guinea pig ventricular trabeculae. DS (50 mumol.L-1) abolished TA induced by ouabain or caffeine, inhibited isoprenaline-induced TA, decreased incidence of TA induced by K(+)-free and high-Ca2+ medium or phenylephrine from 100.75% to 9.1% and 22.2% respectively, and significantly suppressed DAD caused by the above induces. It is concluded that DS exert antagonistic action to DAD and TA in guinea pig trabeculae.