Gambogic Acid
Gambogic Acid structure
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Common Name | Gambogic Acid | ||
|---|---|---|---|---|
| CAS Number | 2752-65-0 | Molecular Weight | 628.751 | |
| Density | 1.3±0.1 g/cm3 | Boiling Point | 808.9±65.0 °C at 760 mmHg | |
| Molecular Formula | C38H44O8 | Melting Point | 88.5°C | |
| MSDS | Chinese USA | Flash Point | 251.4±27.8 °C | |
| Symbol |
GHS06 |
Signal Word | Danger | |
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Induction of programmed erythrocyte death by gambogic acid.
Cell Physiol. Biochem. 30(2) , 428-38, (2012) Gambogic acid, a xanthone from Garcinia hanburyi, stimulates apoptosis and has thus anticancer potency. Similar to apoptosis of nucleated cells, erythrocytes may undergo apoptosis-like suicidal death or eryptosis, which is characterized by cell shrinkage and ... |
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Gambogic acid as a non-competitive inhibitor of ATP-binding cassette transporter B1 reverses the multidrug resistance of human epithelial cancers by promoting ATP-binding cassette transporter B1 protein degradation.
Basic Clin Pharmacol Toxicol. 112(1) , 25-33, (2013) Gambogic acid (GA) is known for its anti-cancer activity in a phase II clinical trial. However, the detailed molecular mechanisms of its anti-multidrug resistance remain unclear. The present study was designed to study the relationship between GA and multidru... |
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Subcellular localization and activity of gambogic acid.
ChemBioChem. 13(8) , 1191-8, (2012) The natural product gambogic acid (GA) has shown significant potential as an anticancer agent as it is able to induce apoptosis in multiple tumor cell lines, including multidrug-resistant cell lines, as well as displaying antitumor activity in animal models. ... |
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Studies on chemical structure modification and structure-activity relationship of derivatives of gambogic acid at C(39).
Chem. Biodivers. 9(8) , 1579-90, (2012) The natural product gambogic acid exhibits high potency in inhibiting cancer cell lines. Rational medicinal modifications on gambogic acid will improve its physicochemical properties and drug-like characters. To investigate the structure-activity relationship... |
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Interaction between Gambogic acid and dihydrofolate reductase and synergistic lethal effects with methotrexate on hepatoma cells.
Anticancer Res. 33(1) , 133-42, (2013) Gambogic acid (GA), a natural xanthone, has a wide spectrum of pharmacological activities, including repression of telomerase expression and induction of apoptosis of cancer cells. GA has also been reported to reduce the steady-state level of thymidylate synt... |
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Gambogic acid inhibits invasion of osteosarcoma via upregulation of TIMP-1.
Int. J. Mol. Med. 31(1) , 105-12, (2013) Gambogic acid (GA), the natural product, has been demonstrated to be a promising chemotherapeutic drug for osteosarcoma (OS) due to its ability to induce apoptosis and cell cycle arrest. To date, no studies have examined the role of GA in metastatic bone dise... |
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Synergistic anti-proliferative effects of gambogic acid with docetaxel in gastrointestinal cancer cell lines.
BMC Complement Altern. Med. 12 , 58, (2012) Gambogic acid has a marked anti-tumor effect for gastric and colorectal cancers in vitro and in vivo. However, recent investigations on gambogic acid have focused mainly on mono-drug therapy, and its potential role in cancer therapy has not been comprehensive... |
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Synthesis and antiangiogenic activity of novel gambogic acid derivatives.
Molecules 17(6) , 6249-68, (2012) Gambogic acid (GA) is in a phase II clinical trial as an antitumor and antiangiogenesis agent. In this study, 36 GA derivatives were synthesized and screened in a zebrafish model to evaluate their antiangiogenic activity and toxicity. Derivatives 4, 32, 35, 3... |
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Gambogic acid protects from endotoxin shock by suppressing pro-inflammatory factors in vivo and in vitro.
Inflamm. Res. 62(2) , 165-72, (2013) Gambogic acid (GBA) targeted Heat shock protein 90 (Hsp90) and prohibited TNF-α/NF-κB signaling pathway. It can be inferred that the anti-inflammatory activity of GBA results from inhibiting the cytokine production via NF-κB signaling pathway. We used the RAW... |
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Design and synthesis of gambogic acid analogs as potent cytotoxic and anti-inflammatory agents
Bioorg. Med. Chem. Lett. 22(12) , 4018-22, (2012) Two pyranoxanthones (16 and 20) showed the greatest activity against the KBvin multidrug resistant (MDR) cell line with IC50 values of 0.9 and 0.8μg/mL, respectively. An angular 3-methyl-3-prenyl pyranoxanthone (17) selectively inhibited elastase release with... |