Andrographolide
Andrographolide structure
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Common Name | Andrographolide | ||
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| CAS Number | 5508-58-7 | Molecular Weight | 350.449 | |
| Density | 1.2±0.1 g/cm3 | Boiling Point | 557.3±50.0 °C at 760 mmHg | |
| Molecular Formula | C20H30O5 | Melting Point | 229-232ºC | |
| MSDS | Chinese USA | Flash Point | 195.5±23.6 °C | |
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Andrographolide prevents high-fat diet-induced obesity in C57BL/6 mice by suppressing the sterol regulatory element-binding protein pathway.
J. Pharmacol. Exp. Ther. 351(2) , 474-83, (2014) Sterol regulatory element-binding proteins (SREBPs) are major transcription factors regulating the expression of genes involved in biosynthesis of cholesterol, fatty acids, and triglycerides. We investigated the effect of the specific SREBP suppressor androgr... |
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Bioavailability of andrographolide and protection against carbon tetrachloride-induced oxidative damage in rats.
Toxicol. Appl. Pharmacol. 280(1) , 1-9, (2014) Andrographolide, a bioactive diterpenoid, is identified in Andrographis paniculata. In this study, we investigated the pharmacokinetics and bioavailability of andrographolide in rats and studied whether andrographolide enhances antioxidant defense in a variet... |
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Andrographolide inhibits TNFα-induced ICAM-1 expression via suppression of NADPH oxidase activation and induction of HO-1 and GCLM expression through the PI3K/Akt/Nrf2 and PI3K/Akt/AP-1 pathways in human endothelial cells.
Biochem. Pharmacol. 91(1) , 40-50, (2014) Andrographolide, the major bioactive component of Andrographis paniculata, has been demonstrated to have various biological properties including anti-inflammation, antioxidation, and anti-hepatotoxicity. Oxidative stress is considered a major risk factor in a... |
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Andrographolide causes apoptosis via inactivation of STAT3 and Akt and potentiates antitumor activity of gemcitabine in pancreatic cancer.
Toxicol. Lett. 222(1) , 23-35, (2013) Gemcitabine is a first-line drug utilised in the chemotherapy of pancreatic cancer; however, this drug induces chemo-resistance and toxicity to normal tissue during treatment. Here, we firstly report that andrographolide (ANDRO) alone not only has anti-pancre... |
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[Study on andrographolide solid dispersion vectored by hydroxyapatite].
Zhongguo Zhong Yao Za Zhi 38(3) , 341-5, (2013) To prepare andrographolide solid dispersion, with hydroxyapatite as vector, in order to increase drug dissolution.Andrographolide and hydroxyapatite were dispersed in 95% ethanol. The solvent evaporation method was adopted to prepare andrographolide solid dis... |
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Determination of andrograpolide sodium bisulphite in Beagle dog plasma by LC-MS/MS and its application to pharmacokinetics.
J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 907 , 173-7, (2012) A sensitive and reliable liquid chromatography-tandem mass spectrometry (LC-MS/MS) has been developed and validated for the determination of andrographolide sodium bisulphite (ASB) in dog plasma using dehydroandrographolide (DAG) as an internal standard. Chro... |
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Antioxidative and cytoprotective effects of andrographolide against CCl4-induced hepatotoxicity in HepG2 cells.
Hum. Exp. Toxicol. 32(5) , 530-43, (2013) This article describes antioxidative and cytoprotective property of andrographolide, a major active component of the plant Andrographis paniculata (A. paniculata). High yields (2.7%) of andrographolide was isolated from the aerial parts of this plant via sili... |
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A green method using a micellar system for determination of andrographolide and dehydroandrographolide in human plasma.
J. Chromatogr. Sci. 51(4) , 341-8, (2013) A method based on cloud point extraction (CPE) coupled with high-performance liquid chromatography separation and ultraviolet (UV) detection was developed to determine andrographolide and dehydroandrographolide in human plasma. The nonionic surfactant Triton ... |
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Effects of andrographolide on the pharmacokinetics of aminophylline and doxofylline in rats.
Drug Res. (Stuttg.) 63(5) , 258-62, (2013) Andrographolide, which is one of the main pharmaceutical ingredients in traditional Chinese medicine Andrographis paniculata, can clear heat, detoxify human body, cool blood and reduce swelling, etc. Respiratory tract infectious diseases have been treated wit... |
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Quantitative analysis of four major diterpenoids in Andrographis paniculata by 1H NMR and its application for quality control of commercial preparations.
J. Pharm. Biomed. Anal. 70 , 87-93, (2012) A quantitative proton nuclear magnetic resonance technique (qHNMR) has been successfully introduced to quantify andrographolide, dehydroandrographolide, deoxyandrographolide and neoandrographolide in Andrographis paniculata, a commonly used important traditio... |