Bergapten
Bergapten structure
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Common Name | Bergapten | ||
|---|---|---|---|---|
| CAS Number | 484-20-8 | Molecular Weight | 216.189 | |
| Density | 1.4±0.1 g/cm3 | Boiling Point | 412.4±45.0 °C at 760 mmHg | |
| Molecular Formula | C12H8O4 | Melting Point | 190-193 °C(lit.) | |
| MSDS | Chinese USA | Flash Point | 203.2±28.7 °C | |
| Symbol |
GHS08 |
Signal Word | Danger | |
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Non-animal photosafety screening for complex cosmetic ingredients with photochemical and photobiochemical assessment tools.
Regul Toxicol Pharmacol 72 , 578-85, (2015) Previously, a non-animal screening approach was proposed for evaluating photosafety of cosmetic ingredients by means of in vitro photochemical and photobiochemical assays; however, complex cosmetic ingredients, such as plant extracts and polymers, could not b... |
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Bergapten drives autophagy through the up-regulation of PTEN expression in breast cancer cells.
Mol. Cancer 14 , 130, (2015) Bergapten (5-methoxypsoralen), a natural psoralen derivative present in many fruits and vegetables, has shown antitumoral effects in a variety of cell types. In this study, it has been addressed how Bergapten in breast cancer cells induces autophagic process.... |
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[Chemical constituents contained in seeds of Notopterygium franchetii].
Zhongguo Zhong Yao Za Zhi 37(7) , 941-5, (2012) To study the chemical constituents from the seeds of Notopterygium franchetii.Ethanol extracts of seeds N. franchetii were separated and purified by such methods as normal and reversed phase column chromatographies and thin-layer chromatography and structural... |
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Visnagin protects against doxorubicin-induced cardiomyopathy through modulation of mitochondrial malate dehydrogenase.
Sci. Transl. Med. 6(266) , 266ra170, (2014) Doxorubicin is a highly effective anticancer chemotherapy agent, but its use is limited by its cardiotoxicity. To develop a drug that prevents this toxicity, we established a doxorubicin-induced cardiomyopathy model in zebrafish that recapitulates the cardiom... |
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Bioactivity-guided isolation of antimicrobial coumarins from Heracleum mantegazzianum Sommier & Levier (Apiaceae) fruits by high-performance counter-current chromatography.
Food Chem. 186 , 133-8, (2015) An efficient strategy, based on bioassay-guided fractionation, high-performance liquid chromatography (HPLC), and high-performance counter-current chromatography (HPCCC), was established to purify and evaluate the bioactive compounds from the dichloromethane ... |
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Cytochrome p450 enzymes mechanism based inhibitors: common sub-structures and reactivity.
Curr. Drug Metab. 6 , 413-54, (2005) The inhibition of human cytochrome P450s (CYPs) is one of the most common mechanisms which can lead to drug-drug interactions. The inhibition of CYPs can be reversible (competitive or non-competitive) or irreversible. Irreversible inhibition usually derives f... |
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Application of the equivalency factor concept to the phototoxicity and –genotoxicity of furocoumarin mixtures
Food Chem. Toxicol. 68 , 257-66, (2014) • The photo-cytotoxic, -mutagenic, and -clastogenic properties in V79 cells of thirteen furocoumarins (FCs), were analyzed. • Nine FC mixtures including one mixture ‘representing’ FCs in Angelica archangelica extract were tested. • The concept of relative pot... |
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Bergapten induces ER depletion in breast cancer cells through SMAD4-mediated ubiquitination.
Breast Cancer Res. Treat. 136(2) , 443-55, (2012) ERα function is crucial for the development of normal mammary gland as well as in the process of progression of breast cancer cells. Signals that target receptor levels contribute to regulate estrogens effects in the cells. An intricate cross-regulation has b... |
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Antagonistic regulation, yet synergistic defense: effect of bergapten and protease inhibitor on development of cowpea bruchid Callosobruchus maculatus.
PLoS ONE 7(8) , e41877, (2012) The furanocoumarin compound bergapten is a plant secondary metabolite that has anti-insect function. When incorporated into artificial diet, it retarded cowpea bruchid development, decreased fecundity, and caused mortality at a sufficient dose. cDNA microarra... |
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Protective effects of 5-methoxypsoralen against acetaminophen-induced hepatotoxicity in mice.
World J. Gastroenterol. 18(18) , 2197-202, (2012) To investigate the hepatic protective effects of 5-methoxypsoralen (5-MOP) and to learn if 5-MOP causes hepatotoxicity at protective doses.C57BL/6J mice were administrated orally with 5-MOP at doses of 12.5, 25 and 50 mg/kg body weight respectively every morn... |