Trigonelline chloride
Trigonelline chloride structure
|
Common Name | Trigonelline chloride | ||
|---|---|---|---|---|
| CAS Number | 6138-41-6 | Molecular Weight | 173.597 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C7H8ClNO2 | Melting Point | ~260 °C (dec.) | |
| MSDS | Chinese USA | Flash Point | N/A | |
|
Preliminary studies on trigonelline as potential anti-Alzheimer disease agent: determination by hydrophilic interaction liquid chromatography and modeling of interactions with beta-amyloid.
J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 968 , 101-4, (2014) For trigonelline, a quaternary-base pyridine alkaloid of presumed Alzheimer's disease-preventing activity, a method of determination has been proposed, based on the hydrophilic interaction chromatography (HILIC). That method might be applied to study the agen... |
|
|
Conversion of nicotinic acid to trigonelline is catalyzed by N-methyltransferase belonged to motif B' methyltransferase family in Coffea arabica.
Biochem. Biophys. Res. Commun. 452(4) , 1060-6, (2014) Trigonelline (N-methylnicotinate), a member of the pyridine alkaloids, accumulates in coffee beans along with caffeine. The biosynthetic pathway of trigonelline is not fully elucidated. While it is quite likely that the production of trigonelline from nicotin... |
|
|
Pyridine metabolism in tea plants: salvage, conjugate formation and catabolism.
J. Plant Res. 125(6) , 781-91, (2012) Pyridine compounds, including nicotinic acid and nicotinamide, are key metabolites of both the salvage pathway for NAD and the biosynthesis of related secondary compounds. We examined the in situ metabolic fate of [carbonyl-(14)C]nicotinamide, [2-(14)C]nicoti... |
|
|
Structure and in vitro antiparasitic activity of constituents of Citropsis articulata root bark.
J. Nat. Prod. 74 , 2286-9, (2011) From the results of an ethnomedicinal investigation of plants from Uganda with antimalarial activity, Citropsis articulata was selected because of the antiplasmodial effect of an ethyl acetate extract of its root bark. Thus, from the cyclohexane, ethyl acetat... |
|
|
Organic and conventional Coffea arabica L.: a comparative study of the chemical composition and physiological, biochemical and toxicological effects in Wistar rats.
Plant Foods Hum. Nutr. 66(2) , 114-21, (2011) Differentiation between organic and conventional coffee has increased due to the growing demand and high consumption of healthy foods that contain compounds with antioxidant potential, which have been associated with the reduction of chronic diseases. We used... |
|
|
OAT2 catalyses efflux of glutamate and uptake of orotic acid.
Biochem. J. 436(2) , 305-12, (2011) OAT (organic anion transporter) 2 [human gene symbol SLC22A7 (SLC is solute carrier)] is a member of the SLC22 family of transport proteins. In the rat, the principal site of expression of OAT2 is the sinusoidal membrane domain of hepatocytes. The particular ... |
|
|
Comparative genomics and functional analysis of the NiaP family uncover nicotinate transporters from bacteria, plants, and mammals.
Funct. Integr. Genomics 12(1) , 25-34, (2012) The transporter(s) that mediate uptake of nicotinate and its N-methyl derivative trigonelline are not known in plants, and certain mammalian nicotinate transporters also remain unidentified. Potential candidates for these missing transporters include proteins... |
|
|
Identification of H₂O₂ as a major antimicrobial component in coffee.
Food Funct. 2(5) , 265-72, (2011) Coffee shows distinct antimicrobial activity against several bacterial genera. The present study investigated molecular mechanisms and active ingredients mediating the antimicrobial effect of coffee. Depending on concentration, roasted, but not raw coffee bre... |
|
|
Determination of betaines in vegetable oils by capillary electrophoresis tandem mass spectrometry--application to the detection of olive oil adulteration with seed oils.
Electrophoresis 32(11) , 1394-401, (2011) A CE-tandem mass spectrometry (MS²) methodology enabling the simultaneous determination of betaines (glycine betaine, trigonelline, proline betaine and total content of carnitines) in vegetable oils was developed. Betaines were derivatized with butanol previo... |
|
|
Trigonelline ameliorates diabetic hypertensive nephropathy by suppression of oxidative stress in kidney and reduction in renal cell apoptosis and fibrosis in streptozotocin induced neonatal diabetic (nSTZ) rats.
Int. Immunopharmacol. 14(4) , 740-8, (2012) Oxidative stress and apoptotic cell death in kidney have been suggested as contributing factors in the development and complication of diabetes especially in diabetic nephropathy (DN). This study investigated the effects of trigonelline (TG) on the renal func... |