Baicalein
Baicalein structure
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Common Name | Baicalein | ||
|---|---|---|---|---|
| CAS Number | 491-67-8 | Molecular Weight | 270.237 | |
| Density | 1.5±0.1 g/cm3 | Boiling Point | 575.9±50.0 °C at 760 mmHg | |
| Molecular Formula | C15H10O5 | Melting Point | 256-271 °C(lit.) | |
| MSDS | Chinese USA | Flash Point | 225.3±23.6 °C | |
| Symbol |
GHS07 |
Signal Word | Warning | |
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A nicotinic receptor-mediated anti-inflammatory effect of the flavonoid rhamnetin in BV2 microglia.
Fitoterapia 98 , 11-21, (2014) The alpha7 nicotinic acetylcholine receptor (nAChR) is a potential target in neuroinflammation. Screening a plant extract library identified Solidago nemoralis as containing methyl-quercetin derivatives that are relatively selective ligands for the alpha7 nAC... |
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Identification and quantification of phytochemicals in nutraceutical products from green tea by UHPLC-Orbitrap-MS.
Food Chem. 173 , 607-18, (2014) A method has been developed and validated for the simultaneous detection and quantification of phytochemicals in nutraceutical products obtained from green tea. For that purpose, ultra-high performance liquid chromatography coupled to single-stage Orbitrap hi... |
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In vitro sensitization of erythrocytes to programmed cell death following baicalein treatment.
Toxins (Basel.) 6(9) , 2771-86, (2014) The polyphenolic flavonoid Baicalein has been shown to trigger suicidal death or apoptosis of tumor cells and is thus considered for the prevention and treatment of malignancy. Similar to apoptosis of nucleated cells, erythrocytes may enter eryptosis, the sui... |
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Delineation of Platelet Activation Pathway of Scutellarein Revealed Its Intracellular Target as Protein Kinase C.
Biol. Pharm. Bull. 39 , 181-91, (2016) Erigeron breviscapus has been widely used in traditional Chinese medicine (TCM) and its total flavonoid component is commonly used to treat ischemic stroke, coronary heart disease, diabetes and hypertension. Scutellarin is the major ingredient of E. breviscap... |
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Baicalein and hydroxypropyl-γ-cyclodextrin complex in poloxamer thermal sensitive hydrogel for vaginal administration.
Int. J. Pharm. 454(1) , 125-34, (2013) The present study aimed to prepare a chemically and physically stable formulation of baicalein (Ba) in an in situ thermally sensitive hydrogel for vaginal administration. An inclusion complex of Ba and hydroxypropyl-γ-cyclodextrin (HP-γ-CD) was first develope... |
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Fisetin, a dietary flavonoid, induces apoptosis of cancer cells by inhibiting HSF1 activity through blocking its binding to the hsp70 promoter.
Carcinogenesis 36 , 696-706, (2015) Heat shock factor 1 (HSF1) is a transcription factor for heat shock proteins (HSPs) expression that enhances the survival of cancer cells exposed to various stresses. HSF1 knockout suppresses carcinogen-induced cancer induction in mice. Therefore, HSF1 is a p... |
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Baicalein Decreases Hydrogen Peroxide-Induced Damage to NG108-15 Cells via Upregulation of Nrf2.
J. Cell Physiol. 230 , 1840-51, (2015) Baicalein is a flavonoid inhibitor of 12-lipoxygenase. Here, we investigated its effect on hydrogen peroxide-induced damage to NG108-15 cells. Hydrogen peroxide activated the mitochondrial apoptotic pathway, decreased Nrf2 expression, increased reactive oxyge... |
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Cuminaldehyde as the Major Component of Cuminum cyminum, a Natural Aldehyde with Inhibitory Effect on Alpha-Synuclein Fibrillation and Cytotoxicity.
J. Food Sci. 80 , H2336-45, (2015) Fibrillation of alpha-synuclein (α-SN) is a critical process in the pathophysiology of several neurodegenerative diseases, especially Parkinson's disease. Application of bioactive inhibitory compounds from herbal extracts is a potential therapeutic approach f... |
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Anticancer effects of baicalein on hepatocellular carcinoma cells.
Phytother Res. 28(9) , 1342-8, (2014) The therapeutic potential of baicalein against hepatoma cells was evaluated in vitro and in vivo. In cell viability assays, baicalein showed significant cytotoxicity against the hepatocellular carcinoma cell lines H22, Bel-7404, and Hep G2 and moderate cytoto... |
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Extraction and Bioactivity Analysis of Major Flavones Compounds from Scutellaria baicalensis Using In Vitro Assay and Online Screening HPLC-ABTS System.
J. Anal. Methods Chem. 2014 , 563702, (2014) The extraction efficiency of a number of solvent compositions for the improvement of bioactive compounds yield from S. baicalensis has been investigated. Also, free radical scavengers in the glycoside baicalin (BG), wogonoside (WG), aglycon baicalein (B), and... |