Aconitine
Aconitine structure
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Common Name | Aconitine | ||
|---|---|---|---|---|
| CAS Number | 302-27-2 | Molecular Weight | 645.737 | |
| Density | 1.4±0.1 g/cm3 | Boiling Point | 717.2±60.0 °C at 760 mmHg | |
| Molecular Formula | C34H47NO11 | Melting Point | 200-205ºC (dec.) | |
| MSDS | Chinese USA | Flash Point | 387.6±32.9 °C | |
| Symbol |
GHS06 |
Signal Word | Danger | |
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Pyrethroids and Nectar Toxins Have Subtle Effects on the Motor Function, Grooming and Wing Fanning Behaviour of Honeybees (Apis mellifera).
PLoS ONE 10 , e0133733, (2015) Sodium channels, found ubiquitously in animal muscle cells and neurons, are one of the main target sites of many naturally-occurring, insecticidal plant compounds and agricultural pesticides. Pyrethroids, derived from compounds found only in the Asteraceae, a... |
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Cryptocoryne spiralis, a substitute of Aconitum heterophyllum in the treatment of diarrhoea.
J. Pharm. Pharmacol. 66(12) , 1808-17, (2014) To scientifically validate the traditional substitution of roots of highly expensive Aconitum heterophyllum (AH) with rhizomes of Cryptocoryne spiralis (CS) in the treatment of diarrhoea.Different fractions from root/rhizome extract of both the plant were sub... |
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A method for analysis of wilfordmine in human plasma by liquid chromatography coupled with ion trap mass spectrometry.
J. Chromatogr. Sci. 53(1) , 177-82, (2014) A simple and rapid liquid chromatography-ion trap mass spectrometric (LC-IT/MS) method has been developed and validated for quantification of wilfordmine in human plasma. After the protein precipitation was carried out by acetonitrile and the solution was cle... |
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(R,S)-Ketamine metabolites (R,S)-norketamine and (2S,6S)-hydroxynorketamine increase the mammalian target of rapamycin function.
Anesthesiology 121(1) , 149-59, (2014) Subanesthetic doses of (R,S)-ketamine are used in the treatment of neuropathic pain and depression. In the rat, the antidepressant effects of (R,S)-ketamine are associated with increased activity and function of mammalian target of rapamycin (mTOR); however, ... |
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3,4-Methylenedioxy-methamphetamine induces in vivo regional up-regulation of central nicotinic receptors in rats and potentiates the regulatory effects of nicotine on these receptors.
Neurotoxicology 35 , 41-9, (2013) Nicotine (NIC), the main psychostimulant compound of smoked tobacco, exerts its effects through activation of central nicotinic acetylcholine receptors (nAChR), which become up-regulated after chronic administration. Recent work has demonstrated that the recr... |
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Aconitine-induced Ca2+ overload causes arrhythmia and triggers apoptosis through p38 MAPK signaling pathway in rats.
Toxicol. Appl. Pharmacol. 279(1) , 8-22, (2014) Aconitine is a major bioactive diterpenoid alkaloid with high content derived from herbal aconitum plants. Emerging evidence indicates that voltage-dependent Na(+) channels have pivotal roles in the cardiotoxicity of aconitine. However, no reports are availab... |
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The Combination of Three Natural Compounds Effectively Prevented Lung Carcinogenesis by Optimal Wound Healing.
PLoS ONE 10 , e0143438, (2015) The tumor stroma has been described as "normal wound healing gone awry". We explored whether the restoration of a wound healing-like microenvironment may facilitate tumor healing. Firstly, we screened three natural compounds (shikonin, notoginsenoside R1 and ... |
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Effects of acute administration of ethanol on experimental arrhythmia.
Chin. J. Physiol. 55(5) , 307-13, (2012) Many studies have shown that the relationship between alcohol consumption and most cardiovascular diseases is U-shaped, with nondrinkers and heavier drinkers having higher risks than moderate drinkers. However, the association between cardiac arrhythmias and ... |
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The exposure of highly toxic aconitine does not significantly impact the activity and expression of cytochrome P450 3A in rats determined by a novel ultra performance liquid chromatography-tandem mass spectrometric method of a specific probe buspirone.
Food Chem. Toxicol. 51 , 396-403, (2013) Aconitum species are widely used to treat rheumatism, cardiovascular diseases, and tumors in China and other Asian countries. The herbs are always used with drugs such as paclitaxel. Aconitine (AC) is one of the main bioactive/high-toxic alkaloids of Aconitum... |
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Effect of α₇ nicotinic acetylcholine receptor agonists and antagonists on motor function in mice.
Toxicol. Appl. Pharmacol. 266(3) , 366-74, (2013) Nicotinic acetylcholine receptors (nAChRs) are ligand-gated cation channels found throughout the body, and serve to mediate diverse physiological functions. Muscle-type nAChRs located in the motor endplate region of muscle fibers play an integral role in musc... |