Catalpol
Catalpol structure
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Common Name | Catalpol | ||
|---|---|---|---|---|
| CAS Number | 2415-24-9 | Molecular Weight | 362.329 | |
| Density | 1.7±0.1 g/cm3 | Boiling Point | 675.6±55.0 °C at 760 mmHg | |
| Molecular Formula | C15H22O10 | Melting Point | 203-205ºC | |
| MSDS | Chinese USA | Flash Point | 362.4±31.5 °C | |
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HPLC-APCI-MS/MS method for the determination of catalpol in rat plasma and cerebrospinal fluid: application to an in vivo pharmacokinetic study.
J. Pharm. Biomed. Anal. 70 , 337-43, (2012) Catalpol is a Chinese herb ingredient with potential for the treatment of neurodegenerative disorders. A high-performance liquid chromatography-atmospheric pressure chemical ionization-tandem mass spectrometry (HPLC-APCI-MS/MS) method was developed and valida... |
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[Simultaneous determination and optimization of extraction process of catalpol and acteoside from rehmanniae radix].
Zhong Yao Cai 35(8) , 1318-22, (2012) To establish a method for simultaneously quantification of the Catalpol and Acteoside from Rehmanniae Radix and optimize the extraction process from Rehmanniae Radix by response surface methodology (RSM) using central composite design (CCD).The effect of etha... |
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Synergistic effects of iridoid glycosides on the survival, development and immune response of a specialist caterpillar, Junonia coenia (Nymphalidae).
J. Chem. Ecol. 38(10) , 1276-84, (2012) Plants use a diverse mix of defenses against herbivores, including multiple secondary metabolites, which may affect herbivores synergistically. Chemical defenses also can affect natural enemies of herbivores via limiting herbivore populations or by affecting ... |
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Plant community diversity influences allocation to direct chemical defence in Plantago lanceolata.
PLoS ONE 6(12) , e28055, (2011) Forecasting the consequences of accelerating rates of changes in biodiversity for ecosystem functioning requires a mechanistic understanding of the relationships between the structure of biological communities and variation in plant functional characteristics... |
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Effect of high relative humidity on dried Plantago lanceolata L. leaves during long-term storage: effects on chemical composition, colour and microbiological quality.
Phytochem. Anal. 23(1) , 88-93, (2012) Modern phytotherapy and quality assurance requires stability data on bioactive metabolites to identify and minimise decomposing factors during processing and storage. A compound's stability in a complex matrix can be different from the stability of the purifi... |
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Differential performance of a specialist and two generalist herbivores and their parasitoids on Plantago lanceolata.
J. Chem. Ecol. 37(7) , 765-78, (2011) The ability to cope with plant defense chemicals differs between specialist and generalist species. In this study, we examined the effects of the concentration of the two main iridoid glycosides (IGs) in Plantago lanceolata, aucubin and catalpol, on the perfo... |
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Caterpillar chemical defense and parasitoid success: Cotesia congregata parasitism of Ceratomia catalpae.
J. Chem. Ecol. 36(9) , 992-8, (2010) Sequestration of plant compounds by herbivorous insects as a defense against predators is well documented; however, few studies have examined the effectiveness of sequestration as a defense against parasitoids. One assumption of the "nasty host" hypothesis is... |
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Oral supplementation of catalpol ameliorates diabetic encephalopathy in rats.
Brain Res. 1307 , 158-65, (2010) Diabetes mellitus can cause dysfunction of the central nervous system called "diabetic encephalopathy." Although insulin and various oral drugs are used to treat diabetes, they do not completely prevent the development of diabetic encephalopathy, and novel st... |
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Catalpol attenuates MPTP induced neuronal degeneration of nigral-striatal dopaminergic pathway in mice through elevating glial cell derived neurotrophic factor in striatum.
Neuroscience 167(1) , 174-84, (2010) The protective effect of an iridoid catalpol extracted and purified from the traditional Chinese medicinal herb Rehmannia glutinosa on the neuronal degeneration of nigral-striatal dopaminergic pathway was studied in a chronic 1-methyl-4-phenyl-1,2,3,4-tetrahy... |
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Enhancement of antiproliferative activity by molecular simplification of catalpol
Bioorg. Med. Chem. 18(7) , 2515-23, (2010) Molecular simplification of any given natural or synthetic template helps medicinal chemists designing shorten synthetic routes while keeping or enhancing the biological activity. This strategy is exemplified with simplified analogs of naturally occurring cat... |