Bioorganic & Medicinal Chemistry 2010-04-01

Enhancement of antiproliferative activity by molecular simplification of catalpol

Celina García, Leticia G. León, Carlos R. Pungitore, Carla Ríos-Luci, Antonio H. Daranas, Juan C. Montero, Atanasio Pandiella, Carlos E. Tonn, Víctor S. Martín, José M. Padrón

Index: Bioorg. Med. Chem. 18(7) , 2515-23, (2010)

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Abstract

Molecular simplification of any given natural or synthetic template helps medicinal chemists designing shorten synthetic routes while keeping or enhancing the biological activity. This strategy is exemplified with simplified analogs of naturally occurring catalpol.