Vindoline
Vindoline structure
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Common Name | Vindoline | ||
|---|---|---|---|---|
| CAS Number | 2182-14-1 | Molecular Weight | 456.531 | |
| Density | 1.3±0.1 g/cm3 | Boiling Point | 569.8±50.0 °C at 760 mmHg | |
| Molecular Formula | C25H32N2O6 | Melting Point | 163-165ºC | |
| MSDS | Chinese USA | Flash Point | 298.4±30.1 °C | |
| Symbol |
GHS08 |
Signal Word | Warning | |
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Increased availability of tryptophan in 5-methyltryptophan-tolerant shoots of Catharanthus roseus and their postharvest in vivo elicitation induces enhanced vindoline production.
Appl. Biochem. Biotechnol. 168(3) , 568-79, (2012) Ten 5-methyltryprophan (5-MT)-resistant multiple shoot culture lines in three genotypes of Catharanthus roseus were selected in vitro. The variant shoot lines displayed a differential threshold tolerance limit against the analogue stress, ranged from 20 to 70... |
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Simultaneous determination of vinblastine and its monomeric precursors vindoline and catharanthine in Catharanthus roseus by capillary electrophoresis-mass spectrometry.
J. Sep. Sci. 34 , 2885-2892, (2011) Catharanthus roseus is an important dicotyledonous medicinal plant that contains various anticancer components, such as vinblastine (VLB) and its monomeric precursors (vindoline and catharanthine). A capillary electrophoresis-mass spectrometry (CE-MS) approac... |
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Catharanthine C16 substituent effects on the biomimetic coupling with vindoline: preparation and evaluation of a key series of vinblastine analogues.
Bioorg. Med. Chem. Lett. 20(22) , 6408-10, (2010) The examination of the catharanthine C16 substituent effects on the Fe(III)-promoted biomimetic coupling reaction with vindoline is detailed, confirming the importance of the presence of a C16 electron-withdrawing substituent, and establishing an unanticipate... |
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Synthesis of difluorocatharanthine and investigation of its biomimetic coupling with vindoline.
Chemistry 19(4) , 1170-3, (2013)
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Synthesis of fluorinated catharanthine analogues and investigation of their biomimetic coupling with vindoline.
Org. Biomol. Chem. 11(35) , 5885-91, (2013) The syntheses of 20,20-difluorocatharanthine and congeners, starting from the naturally occurring catharanthine, are reported. The fluorinated catharanthine analogues were investigated as potential precursors to dimeric Vinca alkaloids of the vinflunine famil... |
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Elaboration of simplified vinca alkaloids and phomopsin hybrids.
Chem. Biol. Drug Des. 75(3) , 284-94, (2010) Nine simplified vinca alkaloids and phomospin A hybrids, in which vindoline moiety has been replaced by a simpler scaffold, have been elaborated to evaluate their activity on the inhibition of tubulin polymerization. This article deals with the synthesis of v... |
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Negative-pressure cavitation extraction of four main vinca alkaloids from Catharanthus roseus leaves.
Molecules 17(8) , 8742-52, (2012) In the present study, an improved method termed negative-pressure cavitation extraction (NPCE) followed by reverse phase high-performance liquid chromatography (RP-HPLC) was developed for the extraction and quantification of vindoline (VDL), catharanthine (CT... |
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[Effects of water stress and nitrogen nutrition on regulation of Catharanthus roseus alkaloids metabolism].
Zhongguo Zhong Yao Za Zhi 37(10) , 1346-52, (2012) Under various drought conditions and nitrogen application, the content of vindoline, catharanthine, vincristine and vinblastine in the leaf of Catharanthus roseus were illustrated to improve the content of alkaloid theoretically.Six groups were set in the exp... |
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Induction and flow cytometry identification of tetraploids from seed-derived explants through colchicine treatments in Catharanthus roseus (L.) G. Don.
J. Biomed. Biotechnol. 2011 , 793198, (2011) The tetraploid plants of Catharanthus roseus (L.) G. Don was obtained by colchicine induction from seeds explants, and the ploidy of the plants was identified by flow cytometry. The optimal treatment is 0.2% colchicine solution treated for 24 hours, and the i... |
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[Distribution and accumulation of vindoline, catharanthine and vinblastine in Catharanthus roseus cultivated in China].
Zhongguo Zhong Yao Za Zhi 35(23) , 3093-6, (2010) The content of vindoline, catharanthine and vinblastine in the root, stem, leaf, flower and fruit of Catharanthus roseus at various developmental stages were determined, and the biomass allocation was also determined to find the best harvest time.The content ... |