4-(((2-Amino-4-oxo-3,4-dihydropteridin-6-yl)methyl)amino)benzoic acid
4-(((2-Amino-4-oxo-3,4-dihydropteridin-6-yl)methyl)amino)benzoic acid structure
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Common Name | 4-(((2-Amino-4-oxo-3,4-dihydropteridin-6-yl)methyl)amino)benzoic acid | ||
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| CAS Number | 119-24-4 | Molecular Weight | 312.284 | |
| Density | 1.7±0.1 g/cm3 | Boiling Point | 659.8ºC at 760mmHg | |
| Molecular Formula | C14H12N6O3 | Melting Point | >400ºC | |
| MSDS | Chinese USA | Flash Point | 352.9ºC | |
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Calculation of absolute ligand binding free energy to a ribosome-targeting protein as a function of solvent model.
J. Phys. Chem. B 112(42) , 13411-7, (2008) A comparative analysis is provided of the effect of different solvent models on the calculation of a potential of mean force (PMF) for determining the absolute binding affinity of the small molecule inhibitor pteroic acid bound to ricin toxin A-chain (RTA). S... |
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X-ray crystallographic analysis of the structural basis for the interactions of pokeweed antiviral protein with its active site inhibitor and ribosomal RNA substrate analogs.
Protein Sci. 8(9) , 1765-72, (1999) The pokeweed antiviral protein (PAP) belongs to a family of ribosome-inactivating proteins (RIP), which depurinate ribosomal RNA through their site-specific N-glycosidase activity. We report low temperature, three-dimensional structures of PAP co-crystallized... |
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Activation of excitatory amino acid receptors may mediate the folate-induced stimulation of locomotor activity after bilateral injection into the rat nucleus accumbens.
J. Pharmacol. Exp. Ther. 239(3) , 627-33, (1986) Folic acid (FA) and 5-formyltetrahydrofolic acid (FTHF) have been shown previously to produce a marked stimulation of locomotor activity after bilateral injection into the rat nucleus accumbens. This study was designed to determine whether the hypermotility r... |
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Targeting of nanoparticles: folate receptor.
Methods Mol. Biol. 624 , 249-65, (2010) Nanoparticulate medicines offer the advantage of allowing delivery of large quantities of unmodified drug within the same particle. Nanoparticle uptake by cancer cells can, however, be compromised due to the large size and hydrophilicity of the particle. To c... |
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Synthesis of pteroylglutamic acid (liver L. casei factor) and pteroic acid.
J. Am. Chem. Soc. 70(1) , 23, (1948)
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Synthesis of pteroylglutamic acid (liver L. casei factor) and pteroic acid.
J. Am. Chem. Soc. 70(1) , 19-22, (1948)
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Application of halogeno-ketones to the synthesis of pteridines, including pteroic acid.
Nature 164(4170) , 574, (1949)
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Preclinical evaluation of novel organometallic 99mTc-folate and 99mTc-pteroate radiotracers for folate receptor-positive tumour targeting.
Eur. J. Nucl. Med. Mol. Imaging 33(9) , 1007-16, (2006) The folate receptor (FR) is a valuable tumour marker, since it is frequently overexpressed on various cancer types. The purpose of the present study was to pre-clinically evaluate novel site-specifically modified (99m)Tc(CO)(3) folate (gamma-derivative 4, alp... |
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Activation of folypolyglutamate synthetase by pteroic acid.
Can. J. Biochem. Cell Biol. 63(7) , 777-9, (1985) The glutamylation of methotrexate catalyzed by beef liver folypolyglutamate synthetase (FPGS) is activated by addition of pteroic acid. Pteroic acid causes greater stimulation of FPGS, including glutamylation of tetrahydrofolate, at neutral pH values (i.e., b... |
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Preparation and purification of pteroic acid from pteroylglutamic acid (folic acid).
Meth. Enzymol. 66 , 657-60, (1980)
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