Pyrimidin-2,4,6-triamin
Pyrimidin-2,4,6-triamin structure
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Common Name | Pyrimidin-2,4,6-triamin | ||
|---|---|---|---|---|
| CAS Number | 1004-38-2 | Molecular Weight | 125.132 | |
| Density | 1.5±0.1 g/cm3 | Boiling Point | 530.8±53.0 °C at 760 mmHg | |
| Molecular Formula | C4H7N5 | Melting Point | 249-251 °C(lit.) | |
| MSDS | Chinese USA | Flash Point | 308.2±18.1 °C | |
| Symbol |
GHS07 |
Signal Word | Warning | |
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Determination of the driving force for the sodium pump (ENa) and of active and passive conductances (GNa and Gsh) in isolated toad skin: influence of antidiuretic hormone.
Gen. Pharmacol. 18(6) , 589-92, (1987) 1. Values of the sodium potential (ENa), active conductance (GNa) and passive conductance (Gsh) were measured in the isolated skin of the toad Pleurodema thaul placed in an Ussing chamber, and Isaacson's test was performed with 2,4,6-trieminopyrimidine (TAP) ... |
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Mechanism of ammonium transport by intestinal segments following urinary diversion: evidence for ionized NH4+ transport via K(+)-pathways.
J. Urol. 148(2 Pt 1) , 453-7, (1992) Using a previously reported in vivo intestinal perfusion model in the rat, we have shown that net total ammonium absorption accounts for the majority of the acid load resulting from urinary intestinal diversion. In the present study, by varying perfusate pH a... |
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Factors affecting the potassium concentration at the mucosal surface of the proximal and the distal colon of guinea pig.
Gut 31(1) , 64-9, (1990) K+ concentrations were measured in vitro with K+ sensitive microelectrodes in the microclimate at the luminal cell surface of the colon of guinea pigs. The serosal K+ concentration was mostly 5.4 mmol/1, the mucosal K+ concentrations were changed (0, 5, 50, o... |
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Competitive blocking of epithelial sodium channels by organic cations: the relationship between macroscopic and microscopic inhibition constants.
J. Membr. Biol. 76(3) , 235-51, (1983) Fluctuation analysis of Na current passing the apical membrane in the skin of Rana ridibunda was used to study the kinetics of Na-channel blocking by several organic cations present in the outer solution together with 60 mM Na. The ratios of the apparent off-... |
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Carbon protonation of 2,4,6-triaminopyrimidines: synthesis, NMR studies, and theoretical calculations.
J. Org. Chem. 71(13) , 4910-8, (2006) Several C5-substituted 2,4,6-triaminopyrimidine derivatives and their HBF4 salts were synthesized to study the carbon protonation of the pyrimidine ring. NMR investigations in DMSO-d6 prove experimentally that, in addition to the usual protonation at N1, the ... |
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Synthesis and biological evaluation of novel pyrimidine derivatives as sub-micromolar affinity ligands of GalR2
Bioorg. Med. Chem. Lett. 21(23) , 7210-5, (2011) GalR1 and GalR2 represent unique pharmacological targets for treatment of seizures and epilepsy. A novel series of 2,4,6-triaminopyrimidine derivatives were synthesized and found to have sub-micromolar affinity for GalR2. Optimization of a series of 2,4,6-tri... |
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Gum arabic (GA) modifies paracellular water and electrolyte transport in the small intestine.
Dig. Dis. Sci. 48(4) , 755-60, (2003) Previous experiments have shown that a soluble fiber, gum arabic (GA), enhances water, electrolyte, and glucose absorption in animal models of diarrhea. The mechanisms implicated in this effect have not been fully elucidated. This study examined the possibili... |
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Electrochemical behavior and voltammetric determination of 2,4,6-triaminopyrimidine at glassy carbon electrode modified with multi-walled carbon nanotubes/nafion.
Anal. Sci. 26(10) , 1071-5, (2010) A multi-wall carbon nanotubes (MWCNTs) composite with Nafion was modified on a glass carbon electrode. The modified electrode was then used as a voltammetric sensor in detecting 2,4,6-triaminopyrimidine (TAP). The surface morphology of the Nafion/MWCNTs compo... |
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Rational Re-engineering of a Transcriptional Silencing PreQ1 Riboswitch.
J. Am. Chem. Soc. 137 , 9015-21, (2015) Re-engineered riboswitches that no longer respond to cellular metabolites, but that instead can be controlled by synthetic molecules, are potentially useful gene regulatory tools for use in synthetic biology and biotechnology fields. Previously, extensive gen... |
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Independence of net water flux from paracellular permeability in the intestine of Fundulus heteroclitus, a euryhaline teleost.
J. Exp. Biol. 215(Pt 3) , 508-17, (2012) Paracellular permeability and absorptive water flux across the intestine of the euryhaline killifish were investigated using in vitro gut sac preparations from seawater- and freshwater-acclimated animals. The permeability of polyethylene glycol (PEG), a well-... |