Tacrolimus
Tacrolimus structure
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Common Name | Tacrolimus | ||
|---|---|---|---|---|
| CAS Number | 104987-11-3 | Molecular Weight | 804.018 | |
| Density | 1.2±0.1 g/cm3 | Boiling Point | 871.7±75.0 °C at 760 mmHg | |
| Molecular Formula | C44H69NO12 | Melting Point | 113-115°C | |
| MSDS | N/A | Flash Point | 481.0±37.1 °C | |
| Symbol |
GHS02, GHS07 |
Signal Word | Danger | |
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Unique drug screening approach for prion diseases identifies tacrolimus and astemizole as antiprion agents.
Proc. Natl. Acad. Sci. U. S. A. 110(17) , 7044-9, (2013) Prion diseases such as Creutzfeldt-Jakob disease (CJD) are incurable and rapidly fatal neurodegenerative diseases. Because prion protein (PrP) is necessary for prion replication but dispensable for the host, we developed the PrP-FRET-enabled high throughput a... |
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Predictive factors of allosensitization after immunosuppressant withdrawal in recipients of long-term cultured islet cell grafts.
Transplantation 96(2) , 162-9, (2013) Islet transplantation has been reported to induce allosensitization in the majority of type 1 diabetic recipients of fresh or shortly incubated islet grafts prepared from one to three donors.We examined the appearance of human leukocyte antigen (HLA) antibodi... |
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Effects of rapamycin and tacrolimus on mature endothelial cells and endothelial progenitor cells.
J. Pak. Med. Assoc. 62(8) , 822-5, (2012) To investigate the effects of the potent immunosuppressive agents tacrolimus and rapamycin on the number of circulating mature endothelial cells and circulating endothelial progenitor cells in an experimental model.It was an experimental study performed from ... |
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Impact of late calcineurin inhibitor withdrawal on ambulatory blood pressure and carotid intima media thickness in renal transplant recipients.
Transplantation 96(1) , 49-57, (2013) Calcineurin inhibitors (CNIs) have an unfavorable cardiovascular risk profile in renal transplant recipients. The aim of this substudy was to assess the effects of late CNI or mycophenolate mofetil (MMF) withdrawal on ambulatory blood pressure monitoring and ... |
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New-onset diabetes after transplantation (NODAT): an evaluation of definitions in clinical trials.
Transplantation 96(1) , 58-64, (2013) New-onset diabetes after transplantation (NODAT) occurs commonly. Prior NODAT definitions have been inconsistent. Based on the American Diabetic Association criteria, we propose a new approach to defining NODAT.Analysis of 1416 at-risk transplant recipients w... |
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Use of cyclosporine A and tacrolimus in treatment of vernal keratoconjunctivitis.
Curr. Allergy Asthma Rep. 13(3) , 308-14, (2013) Vernal keratoconjunctivitis is a sight-threatening inflammatory disease of conjunctiva and cornea. It is frequently observed in young children with the onset usually occurring in the first decade of life. Mild cases of VKC tend to remit with nonspecific and s... |
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Preventing graft-versus-host disease: transplanters glimpse hope beyond immunosuppressants.
J. Natl. Cancer Inst. 105(13) , 922-3, (2013)
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Up-regulation of alternate co-stimulatory molecules on proinflammatory CD28null T cells in bronchiolitis obliterans syndrome.
Clin. Exp. Immunol. 173(1) , 150-60, (2013) Bronchiolitis obliterans syndrome (BOS) is associated with lack of immunosuppression of T cell proinflammatory cytokines and increased T cell granzyme B. Repeated antigen-driven proliferation down-regulates T cell CD28. We hypothesized that down-regulation of... |
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Tacrolimus in steroid resistant and steroid dependent childhood nephrotic syndrome.
J. Med. Assoc. Thai. 96(1) , 33-40, (2013) To evaluate the efficacy of tacrolimus (Tac) in steroid resistant and steroid dependent nephrotic syndrome (NS) in children.Retrospective chart reviews of 18 children from outpatient clinic at the Department of Pediatrics, Faculty of Medicine Siriraj Hospital... |
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Genetic and genomic architecture of the evolution of resistance to antifungal drug combinations.
PLoS Genet. 9(4) , e1003390, (2013) The evolution of drug resistance in fungal pathogens compromises the efficacy of the limited number of antifungal drugs. Drug combinations have emerged as a powerful strategy to enhance antifungal efficacy and abrogate drug resistance, but the impact on the e... |