H-Phe-Gly-OH
H-Phe-Gly-OH structure
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Common Name | H-Phe-Gly-OH | ||
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| CAS Number | 721-90-4 | Molecular Weight | 222.24000 | |
| Density | 1.259g/cm3 | Boiling Point | 512.5ºC at 760 mmHg | |
| Molecular Formula | C11H14N2O3 | Melting Point | -260ºC (dec.) | |
| MSDS | Chinese USA | Flash Point | 263.7ºC | |
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Hydrogen exchange equilibria in thiols.
Chem. Res. Toxicol. 25(9) , 1862-7, (2012) Cysteine, cysteinyl-glycine, glutathione, phenylalanyl-cysteinyl-glycine, and histidyl-cysteinyl-glycine were dissolved in acidic and neutral D(2)O in the presence of the radical generator 2,2'-azobis(2-methylpropionamidine) dihydrochloride and radical mediat... |
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Enhanced transdermal delivery of phenylalanyl-glycine by chemical modification with various fatty acids.
Int. J. Pharm. 250(1) , 119-28, (2003) We synthesized three novel lipophilic derivatives of phenylalanyl-glycine (Phe-Gly), C4-Phe-Gly, C6-Phe-Gly and C8-Phe-Gly by chemical modification with butyric acid (C4), caproic acid (C6) and octanoic acid (C8). The effect of the acylation on the stability,... |
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Enhancement of the small intestinal uptake of phenylalanylglycine via a H+/oligopeptide transport system by chemical modification with fatty acids.
Life Sci. 61(25) , 2455-65, (1997) The transport characteristics of chemically modified phenylalanylglycine (Phe-Gly) with butyric acid (C4-Phe-Gly) and caproic acid (C6-Phe-Gly) were examined using rabbit intestinal brush-border membrane vesicles (BBMVs). In the presence of an inwardly H+ gra... |
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Molecular mechanism of the inhibition of cytochrome c aggregation by Phe-Gly.
Arch. Biochem. Biophys. 435(1) , 182-9, (2005) Experimental and computational studies suggest that few general principles govern protein/protein interactions and aggregation. The knowledge of these rules may be exploited to design peptides that are able to interfere with the self-assembly and aggregation ... |
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Peptide ordering within nuclear pores in living cells.
Biophys. J. 104(1) , 6-7, (2013)
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Design, synthesis, and evaluation of Phe-Gly mimetics: heterocyclic building blocks for pseudopeptides.
J. Med. Chem. 42(21) , 4331-42, (1999) Enantiopure heterocyclic Boc-protected Phe-Gly dipeptidomimetics containing 1,3,4-oxadiazole, 1,2,4-oxadiazole, and 1,2,4-triazole ring systems have been synthesized as building blocks in the synthesis of pseudopeptides. Three derivatives (1-3) have the carbo... |
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Carrier-mediated transport of cephalexin via the dipeptide transport system in rat renal brush-border membrane vesicles.
Biochim. Biophys. Acta 769(2) , 449-54, (1984) Carrier-mediated transport of aminocephalosporin antibiotics by renal brush-border membrane vesicles has been studied in relation to the transport systems for dipeptides and amino acids. Dipeptides such as L-carnosine (beta-alanyl-L-histidine) and L-phenylala... |
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Nuclear transport receptor binding avidity triggers a self-healing collapse transition in FG-nucleoporin molecular brushes.
Proc. Natl. Acad. Sci. U. S. A. 109(42) , 16911-6, (2012) Conformational changes at supramolecular interfaces are fundamentally coupled to binding activity, yet it remains a challenge to probe this relationship directly. Within the nuclear pore complex, this underlies how transport receptors known as karyopherins pr... |
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Phe-Gly dipeptidomimetics designed for the di-/tripeptide transporters PEPT1 and PEPT2: synthesis and biological investigations.
J. Med. Chem. 47(4) , 1060-9, (2004) A series of five Phe-Gly dipeptidomimetics containing different amide bond replacements have been synthesized in a facile way from the readily available unsaturated ketoester 1, and their affinities for the di-/tripeptide transporters hPEPT1 (Caco-2 cells) an... |
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In vivo nephrotoxic action of an isomeric mixture of S-(1-phenyl-2-hydroxyethyl)glutathione and S-(2-phenyl-2-hydroxyethyl)glutathione in Fischer-344 rats.
Toxicology 67(1) , 15-27, (1991) An isomeric mixture of S-[(1 and 2)-phenyl-2-hydroxyethyl]glutathione (PHEG), a glutathione conjugate of styrene, is moderately nephrotoxic. Its in vivo nephrotoxicity was characterized by significant elevations in the urinary excretion of glucose, gamma-glut... |