AGK2
AGK2 structure
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Common Name | AGK2 | ||
|---|---|---|---|---|
| CAS Number | 304896-28-4 | Molecular Weight | 434.274 | |
| Density | 1.4±0.1 g/cm3 | Boiling Point | 675.1±55.0 °C at 760 mmHg | |
| Molecular Formula | C23H13Cl2N3O2 | Melting Point | N/A | |
| MSDS | USA | Flash Point | 362.1±31.5 °C | |
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Functionalized tetrahydro-1H-pyrido[4,3-b]indoles: a novel chemotype with Sirtuin 2 inhibitory activity.
Eur. J. Med. Chem. 92 , 145-55, (2015) Sirtuins are protein deacylases with regulatory roles in metabolism and stress response. Functionalized tetrahydro-1H-pyrido[4,3-b]indoles were identified as preferential sirtuin 2 inhibitors, with in vitro inhibitory potencies in the low micromolar concentra... |
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SIRT2 ameliorates lipopolysaccharide-induced inflammation in macrophages.
Biochem. Biophys. Res. Commun. 450(4) , 1363-9, (2014) SIRT2 is a NAD(+)-dependent deacetylases and associated with numerous processes such as infection, carcinogenesis, DNA damage and cell cycle regulation. However, the role of SIRT2 in inflammatory process in macrophage remains unclear.In the present study, we ... |
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Specific ablation of Nampt in adult neural stem cells recapitulates their functional defects during aging.
EMBO J. 33(12) , 1321-40, (2014) Neural stem/progenitor cell (NSPC) proliferation and self-renewal, as well as insult-induced differentiation, decrease markedly with age. The molecular mechanisms responsible for these declines remain unclear. Here, we show that levels of NAD(+) and nicotinam... |
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Tissue-specific deregulation of selected HDACs characterizes ALS progression in mouse models: pharmacological characterization of SIRT1 and SIRT2 pathways.
Cell Death Dis. 5 , e1296, (2014) Acetylation homeostasis is thought to play a role in amyotrophic lateral sclerosis, and treatment with inhibitors of histone deacetylases has been considered a potential and attractive therapeutic approach, despite the lack of a thorough study of this class o... |
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Sirtuin inhibitors, EX527 and AGK2, suppress cell migration by inhibiting HSF1 protein stability.
Oncol. Rep. 35 , 235-42, (2015) The histone deacetylases (HDACs), Sirtuin 1 (Sirt1) and Sirt2, play crucial roles in many biological processes, including cell proliferation, differentiation and apoptosis. HDAC inhibitors have been considered as a potential therapeutic approach for various t... |
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Blocking sirtuin 1 and 2 inhibits renal interstitial fibroblast activation and attenuates renal interstitial fibrosis in obstructive nephropathy.
J. Pharmacol. Exp. Ther. 350(2) , 243-56, (2014) Our recent studies revealed that blocking class I/II histone deacetylases (HDACs) inhibits renal interstitial fibroblast activation and proliferation and alleviates development of renal fibrosis. However, the effect of class III HDAC, particularly sirtuin 1 a... |
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ER stress-associated CTRC mutants decrease stimulated pancreatic zymogen secretion through SIRT2-mediated microtubule dysregulation.
Biochem. Biophys. Res. Commun. 463 , 329-35, (2015) Pancreatitis has been suspected for a long time to have an autodigestive genesis. The main events occurring in the pancreatic acinar cell that initiate acute pancreatitis include inhibition of zymogen secretion and intracellular activation of proteases. Chymo... |
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Expression/localization patterns of sirtuins (SIRT1, SIRT2, and SIRT7) during progression of cervical cancer and effects of sirtuin inhibitors on growth of cervical cancer cells.
Tumour Biol. 36 , 6159-71, (2015) Sirtuins belong to the family of class III histone deacetylases; its role in neoplasia is controversial as both tumor-suppressive and promoting functions have been reported. There are very few reports available, where expressions of sirtuin isoforms are compr... |
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Silencing of SIRT2 induces cell death and a decrease in the intracellular ATP level of PC12 cells.
Int. J. Physiol. Pathophysiol. Pharmacol. 3 , 65-70, (2011) Sirtuin 2 (SIRT2), a tubulin deacetylase, is a sirtuin family protein. SIRT2 inhibitors have been shown to decrease the cell death in cellular and Drosophila models of Parkinson's disease. However, SIRT2 decreases may also compromise cellular antioxidation ca... |
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Chemical and microbiological characterisation of kefir grains.
J. Dairy Res. 68 , 639-52, (2001) Chemical and microbiological composition of four Argentinean kefir grains from different sources as well as characteristics of the corresponding fermented milk were studied. Kefir grains CIDCA AGK1, AGK2 and AGK4 did not show significant differences in their ... |