alpha-Amanitin
alpha-Amanitin structure
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Common Name | alpha-Amanitin | ||
|---|---|---|---|---|
| CAS Number | 23109-05-9 | Molecular Weight | 918.97000 | |
| Density | 1.57 g/cm3 | Boiling Point | 1622.2ºC at 760 mmHg | |
| Molecular Formula | C39H54N10O14S | Melting Point | 254-255ºC(lit.) | |
| MSDS | Chinese USA | Flash Point | 934.9ºC | |
| Symbol |
GHS06, GHS08 |
Signal Word | Danger | |
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Arabidopsis RRP6L1 and RRP6L2 function in FLOWERING LOCUS C silencing via regulation of antisense RNA synthesis.
PLoS Genet. 10(9) , e1004612, (2014) The exosome complex functions in RNA metabolism and transcriptional gene silencing. Here, we report that mutations of two Arabidopsis genes encoding nuclear exosome components AtRRP6L1 and AtRRP6L2, cause de-repression of the main flowering repressor FLOWERIN... |
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Thyroid hormone increases bulk histones expression by enhancing translational efficiency.
Mol. Endocrinol. 29(1) , 68-75, (2014) The expression of canonical histones is normally coupled to DNA synthesis during the S phase of the cell cycle. Replication-dependent histone mRNAs do not contain a poly(A) tail at their 3' terminus, but instead possess a stem-loop motif, the binding site for... |
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α-1-antitrypsin inhibits acute liver failure in mice.
Hepatology 59(6) , 2299-308, (2014) Acute liver failure remains a critical clinical condition, with high mortality rates, and increased apoptosis of hepatocytes represents a key event in the cause of liver failure. Alpha-1-antitrypsin (AAT) is synthesized and secreted mainly by hepatocytes, and... |
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Unveiling the bovine embryo transcriptome during the maternal-to-embryonic transition.
Reproduction 137 , 245-57, (2009) Bovine early embryos are transcriptionally inactive and subsist through the initial developmental stages by the consumption of the maternal supplies provided by the oocyte until its own genome activation. In bovine, the activation of transcription occurs duri... |
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Function of histone deacetylase 6 as a cofactor of nuclear receptor coregulator LCoR.
J. Thorac. Cardiovasc. Surg. 284 , 30264-74, (2009) Ligand-dependent corepressor LCoR was identified as a protein that interacts with the estrogen receptor alpha (ERalpha) ligand binding domain in a hormone-dependent manner. LCoR also interacts directly with histone deacetylase 3 (HDAC3) and HDAC6. Notably, HD... |
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Ligand-dependent corepressor LCoR is an attenuator of progesterone-regulated gene expression.
J. Thorac. Cardiovasc. Surg. 284 , 30275-87, (2009) Ligand-dependent corepressor LCoR interacts with the progesterone receptor (PR) and estrogen receptor ERalpha in the presence of hormone. LCoR contains tandem N-terminal PXDLS motifs that recruit C-terminal-binding protein (CtBP) corepressors as well as a C-t... |
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Stochastic and reversible aggregation of mRNA with expanded CUG-triplet repeats.
J. Cell Biol. 124 , 1703-14, (2011) Transcripts containing expanded CNG repeats, which are found in several neuromuscular diseases, are not exported from the nucleus and aggregate as ribonuclear inclusions by an unknown mechanism. Using the MS2-GFP system, which tethers fluorescent proteins to ... |
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C19MC microRNAs are processed from introns of large Pol-II, non-protein-coding transcripts.
Nucleic Acids Res. 37 , 3464-73, (2009) MicroRNAs are tiny RNA molecules that play important regulatory roles in a broad range of developmental, physiological or pathological processes. Despite recent progress in our understanding of miRNA processing and biological functions, little is known about ... |
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Perinuclear P granules are the principal sites of mRNA export in adult C. elegans germ cells.
Development 137 , 1305-14, (2010) Germline-specific granules of unknown function are found in a wide variety of organisms, including C. elegans, where they are called P granules. P granules are cytoplasmic bodies in oocytes and early embryos. Throughout most of the C. elegans life cycle, howe... |
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Micro-RNA abundance and stability in human brain: specific alterations in Alzheimer's disease temporal lobe neocortex.
Neurosci. Lett. 459 , 100-4, (2009) Micro-RNA (miRNA) mediated regulation of messenger RNA (mRNA) complexity in the central nervous system (CNS) is emerging as a critical factor in the control of CNS-specific gene expression during development, plasticity, aging and disease. In these studies, m... |