AZ 11645373
AZ 11645373 structure
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Common Name | AZ 11645373 | ||
|---|---|---|---|---|
| CAS Number | 227088-94-0 | Molecular Weight | 463.51 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C24H21N3O5S | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | N/A | |
| Symbol |
GHS05, GHS07 |
Signal Word | Danger | |
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Characterization of a selective and potent antagonist of human P2X(7) receptors, AZ11645373.
Br. J. Pharmacol. 149 , 880-887, (2006) The ATP-gated P2X(7) receptor has been shown to play a role in several inflammatory processes, making it an attractive target for anti-inflammatory drug discovery. We have recently identified a novel set of cyclic imide compounds that inhibited P2X(7) recepto... |
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Functional evidence for the expression of P2X1, P2X4 and P2X7 receptors in human lung mast cells.
Br. J. Pharmacol. 157 , 1215-24, (2009) P2X receptors are widely expressed in cells of the immune system with varying functions. This study sought to characterize P2X receptor expression in the LAD2 human mast cell line and human lung mast cells (HLMCs).Reverse transcriptase polymerase chain reacti... |
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P2X(7) receptor-mediated release of cathepsins from macrophages is a cytokine-independent mechanism potentially involved in joint diseases.
J. Immunol. 185 , 2611-9, (2010) The ATP-gated P2X(7) receptor (P2X(7)R) is a promising therapeutic target in chronic inflammatory diseases with highly specific antagonists currently under clinical trials for rheumatoid arthritis. Anti-inflammatory actions of P2X(7)R antagonists are consider... |
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Pharmacological properties of the rhesus macaque monkey P2X7 receptor.
Br. J. Pharmacol. 164 , 743-54, (2011) The human P2X7 (hP2X7) receptor exhibits striking pharmacological differences from its rodent counterparts, particularly in terms of its antagonist profile. Here, we characterized the functional and pharmacological properties of the rhesus macaque monkey P2X7... |