1H-Benzimidazole, 6-chloro-2-(trichloromethyl)-

1H-Benzimidazole, 6-chloro-2-(trichloromethyl)- Structure
1H-Benzimidazole, 6-chloro-2-(trichloromethyl)- structure
Common Name 1H-Benzimidazole, 6-chloro-2-(trichloromethyl)-
CAS Number 3584-66-5 Molecular Weight 269.94300
Density 1.704 g/cm3 Boiling Point 380.3ºC at 760 mmHg
Molecular Formula C8H4Cl4N2 Melting Point 223-224ºC (dec.)(lit.)
MSDS Chinese USA Flash Point 215.7ºC
Symbol GHS06
GHS06
Signal Word Danger

Designing small-molecule switches for protein-protein interactions.

Science 288(5473) , 2042-5, (2000)

Mutations introduced into human growth hormone (hGH) (Thr175 --> Gly-hGH) and the extracellular domain of the hGH receptor (Trp104 --> Gly-hGHbp) created a cavity at the protein-protein interface that resulted in binding affinity being reduced by a factor of ...