8-Bromoadenosine
8-Bromoadenosine structure
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Common Name | 8-Bromoadenosine | ||
|---|---|---|---|---|
| CAS Number | 2946-39-6 | Molecular Weight | 346.14 | |
| Density | 2.5±0.1 g/cm3 | Boiling Point | 717.7±70.0 °C at 760 mmHg | |
| Molecular Formula | C10H12BrN5O4 | Melting Point | 210-212 °C (dec.)(lit.) | |
| MSDS | USA | Flash Point | 387.8±35.7 °C | |
| Symbol |
GHS07 |
Signal Word | Warning | |
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PKA signaling drives mammary tumorigenesis through Src.
Oncogene 34(9) , 1160-73, (2015) Protein kinase A (PKA) hyperactivation causes hereditary endocrine neoplasias; however, its role in sporadic epithelial cancers is unknown. Here, we show that heightened PKA activity in the mammary epithelium generates tumors. Mammary-restricted biallelic abl... |
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ADAM12-directed ectodomain shedding of E-cadherin potentiates trophoblast fusion.
Cell Death Differ. 22 , 1970-84, (2015) Trophoblasts, placental cells of epithelial lineage, undergo extensive differentiation to form the cellular components of the placenta. Trophoblast progenitor cell differentiation into the multinucleated syncytiotrophoblast is a key developmental process requ... |
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Prostaglandin E2 Inhibits NLRP3 Inflammasome Activation through EP4 Receptor and Intracellular Cyclic AMP in Human Macrophages.
J. Immunol. 194 , 5472-87, (2015) PGE2 is a potent lipid mediator involved in maintaining homeostasis but also promotion of acute inflammation or immune suppression in chronic inflammation and cancer. Nucleotide-binding domain, leucine-rich repeat-containing protein (NLR)P3 inflammasome plays... |
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Effects of caffeine on circadian phase, amplitude and period evaluated in cells in vitro and peripheral organs in vivo in PER2::LUCIFERASE mice.
Br. J. Pharmacol. 171(24) , 5858-69, (2014) Caffeine is one of the most commonly used psychoactive substances. Circadian rhythms consist of the main suprachiasmatic nucleus (SCN) clocks and peripheral clocks. Although caffeine lengthens circadian rhythms and modifies phase changes in SCN-operated rhyth... |
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Functional characterization of the human facilitative glucose transporter 12 (GLUT12) by electrophysiological methods.
Am. J. Physiol. Cell Physiol. 308 , C1008-22, (2015) GLUT12 is a member of the facilitative family of glucose transporters. The goal of this study was to characterize the functional properties of GLUT12, expressed in Xenopus laevis oocytes, using radiotracer and electrophysiological methods. Our results showed ... |
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Adrenal fasciculata cells express T-type and rapidly and slowly activating L-type Ca2+ channels that regulate cortisol secretion.
Am. J. Physiol. Cell Physiol. 308 , C899-918, (2015) In whole cell patch-clamp recordings, we characterized the L-type Ca(2+) currents in bovine adrenal zona fasciculata (AZF) cells and explored their role, along with the role of T-type channels, in ACTH- and angiotensin II (ANG II)-stimulated cortisol secretio... |
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Decidualization induces a secretome switch in perivascular niche cells of the human endometrium.
Endocrinology 155(11) , 4542-53, (2014) The endometrial perivascular microenvironment is rich in mesenchymal stem-like cells that express type 1 integral membrane protein Sushi domain containing 2 (SUSD2) but the role of these cells in the decidual transformation of this tissue in pregnancy is unkn... |
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Switch in signaling control of mTORC1 activity after oncoprotein expression in thyroid cancer cell lines.
J. Clin. Endocrinol. Metab. 99(10) , E1976-87, (2014) Thyroid growth is regulated by TSH and requires mammalian target of rapamycin (mTOR). Thyroid cancers frequently exhibit mutations in MAPK and/or phosphoinositol-3-kinase-related kinase effectors.The objective of the study was to explore the contribution of R... |
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Bronchoalveolar sublineage specification of pluripotent stem cells: effect of dexamethasone plus cAMP-elevating agents and keratinocyte growth factor.
Tissue Eng. Part A 21(3-4) , 669-82, (2015) Respiratory progenitors can be efficiently generated from pluripotent stem cells (PSCs). However, further targeted differentiation into bronchoalveolar sublineages is still in its infancy, and distinct specifying effects of key differentiation factors are not... |
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Steroid biosynthesis by zona glomerulosa-fasciculata cells in primary culture of guinea-pig adrenals.
J. Steroid Biochem. 36(6) , 589-96, (1990) Steroidogenesis was studied in guinea-pig glomerulosa-fasciculata cells maintained in primary culture for up to 7 days. The basal secretion which remained stable for the first 2 days in culture rapidly rose to reach a plateau on day 4 at levels 6-7-fold highe... |