N-NITROSO-N-ETHYLUREA
N-NITROSO-N-ETHYLUREA structure
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Common Name | N-NITROSO-N-ETHYLUREA | ||
|---|---|---|---|---|
| CAS Number | 759-73-9 | Molecular Weight | 117.10700 | |
| Density | 1.35g/cm3 | Boiling Point | 181.8ºC at 760 mmHg | |
| Molecular Formula | C3H7N3O2 | Melting Point | 103-104ºC (dec) | |
| MSDS | Chinese USA | Flash Point | 63.8ºC | |
| Symbol |
GHS06, GHS08 |
Signal Word | Danger | |
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Genotoxicity assessment of melamine in the in vivo Pig-a mutation assay and in a standard battery of assays.
Mutat. Res. Genet. Toxicol. Environ. Mutagen. 777 , 62-7, (2015) The genotoxicity of melamine was evaluated with the combined Pig-a mutation/micronucleus assay, the bacterial reverse mutation assay, and the in vitro cytokinesis-block micronucleus assay (CBMN). Five groups of six- to eight-week-old male Sprague-Dawley (SD) ... |
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The stress response resolution assay. I. Quantitative assessment of environmental agent/condition effects on cellular stress resolution outcomes in epithelium.
Environ. Mol. Mutagen. 54(4) , 268-80, (2013) The events or factors that lead from normal cell function to conditions and diseases such as aging or cancer reflect complex interactions between cells and their environment. Cellular stress responses, a group of processes involved in homeostasis and adaptati... |
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The stress response resolution assay. II. Quantitative assessment of environmental agent/condition effects on cellular stress resolution outcomes in epithelium.
Environ. Mol. Mutagen. 54(4) , 281-93, (2013) Cellular stress responses consist of a complex network of pathways and linked processes that, when perturbed, are postulated to have roles in the pathogenesis of various human diseases. To assess the impact of environmental insults upon this network, we devel... |
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Enhanced Functional Activity of the Cannabinoid Type-1 Receptor Mediates Adolescent Behavior.
J. Neurosci. 35 , 13975-88, (2015) Adolescence is characterized by drastic behavioral adaptations and comprises a particularly vulnerable period for the emergence of various psychiatric disorders. Growing evidence reveals that the pathophysiology of these disorders might derive from aberration... |
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Development of covalent inhibitors that can overcome resistance to first-generation FGFR kinase inhibitors.
Proc. Natl. Acad. Sci. U. S. A. 111(45) , E4869-77, (2014) The human FGF receptors (FGFRs) play critical roles in various human cancers, and several FGFR inhibitors are currently under clinical investigation. Resistance usually results from selection for mutant kinases that are impervious to the action of the drug or... |
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A forward genetic screen in mice identifies mutants with abnormal cortical patterning.
Cereb. Cortex 25(1) , 167-79, (2014) Formation of a 6-layered cortical plate and axon tract patterning are key features of cerebral cortex development. Abnormalities of these processes may be the underlying cause for a range of functional disabilities seen in human neurodevelopmental disorders. ... |
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ENU mutagenesis identifies mice modeling Warburg Micro Syndrome with sensory axon degeneration caused by a deletion in Rab18.
Exp. Neurol. 267 , 143-51, (2015) Mutations in the gene of RAB18, a member of Ras superfamily of small G-proteins, cause Warburg Micro Syndrome (WARBM) which is characterized by defective neurodevelopmental and ophthalmological phenotypes. Despite loss of Rab18 had been reported to induce dis... |
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Slc15a4 function is required for intact class switch recombination to IgG2c in response to TLR9 stimulation.
Immunol. Cell Biol. 93(2) , 136-46, (2015) Signalling through Toll-like receptors (TLRs) by endogenous components of viruses or bacteria can promote antibody (Ab) isotype switching to IgG2a/c. Multiple cell types are capable of responding to TLR stimulation in vivo and the processes underlying TLR-ind... |
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Evaluation of in vivo mutagenicity of hydroquinone in Muta™ mice.
Mutat. Res. Genet. Toxicol. Environ. Mutagen. 775-776 , 94-8, (2014) Hydroquinone (HQ) is used in skin bleaching agents, hair dyes, and finger nail treatments. Many skin-lightening cosmetics that contain HQ are currently marketed in Japan. Concerns have been expressed regarding health risks to the general population because th... |
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CCDC88B is a novel regulator of maturation and effector functions of T cells during pathological inflammation.
J. Exp. Med. 211(13) , 2519-35, (2014) We used a genome-wide screen in mutagenized mice to identify genes which inactivation protects against lethal neuroinflammation during experimental cerebral malaria (ECM). We identified an ECM-protective mutation in coiled-coil domain containing protein 88b (... |