Cabergoline
Cabergoline structure
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Common Name | Cabergoline | ||
|---|---|---|---|---|
| CAS Number | 81409-90-7 | Molecular Weight | 451.604 | |
| Density | 1.2±0.1 g/cm3 | Boiling Point | N/A | |
| Molecular Formula | C26H37N5O2 | Melting Point | 102-104°C | |
| MSDS | Chinese USA | Flash Point | N/A | |
| Symbol |
GHS07 |
Signal Word | Warning | |
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Cabergoline, dopamine D2 receptor agonist, prevents neuronal cell death under oxidative stress via reducing excitotoxicity.
PLoS ONE 9(6) , e99271, (2014) Several lines of evidence demonstrate that oxidative stress is involved in the pathogenesis of neurodegenerative diseases, including Parkinson's disease. Potent antioxidants may therefore be effective in the treatment of such diseases. Cabergoline, a dopamine... |
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Psychological Stress-Derived Prolactin Modulates Occludin Expression in Vaginal Epithelial Cells to Compromise Barrier Function.
Cell Physiol. Biochem. 37 , 153-61, (2015) The causative factors of the vaginitis are not fully understood yet. Epithelial barrier dysfunction plays a critical role in the pathogenesis of vaginitis. This study aims to investigate the role of prolactin (PRL) in the causing the vaginal epithelial barrie... |
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Cushing's disease and hypertension: in vivo and in vitro study of the role of the renin-angiotensin-aldosterone system and effects of medical therapy.
Eur. J. Endocrinol. 170(2) , 181-91, (2014) Cushing's disease (CD) is often accompanied by hypertension. CD can be treated surgically and, given the expression of somatostatin subtype 5 and dopamine 2 receptors by corticotroph pituitary adenomas, pharmacologically. Indeed, we recently observed that ste... |
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Duration of drug action of dopamine D2 agonists in mice with 6-hydroxydopamine-induced lesions.
Neuroreport 26 , 1126-32, (2015) Although 6-hydroxydopamine-induced (6-OHDA-induced) rats are a well-known Parkinson's disease model, the effects of dopamine D2 agonists in mice with 6-OHDA-induced lesions are not completely understood. We produced mice with 6-OHDA-induced lesions and measur... |
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Effects of cabergoline and rotigotine on tacrine-induced tremulous jaw movements in rats.
Pharmacol. Biochem. Behav. 126 , 103-8, (2014) We examined the effects of two dopamine agonists, cabergoline and rotigotine, on tacrine-induced tremor and c-Fos expression in rats.Rats received intraperitoneal injection of cabergoline (0.5, 1.0, or 5.0mg/kg), rotigotine (1.0, 2.5, or 10.0mg/kg), or vehicl... |
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[Drug therapy for acromegaly].
Orv. Hetil. 154(39) , 1527-34, (2013) Prolonged overproduction of growth hormone, like insulin-like growth factor-1 hypersecretion leads to acromegaly in adults. This is associated with several co-morbidities and increased mortality. Despite typical clinical features and modern diagnostic tools, ... |
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Real-world comorbidities and treatment patterns of patients with acromegaly in two large US health plan databases.
Pituitary 16(3) , 354-62, (2013) Acromegaly is a rare, chronic, and debilitating disease that results from excessive growth hormone production. Clinically, this disease is associated with enlargement of soft tissue, excessive skeletal growth, and increased risk of cardiovascular disease. Acr... |
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Prolactin mediates psychological stress-induced dysfunction of regulatory T cells to facilitate intestinal inflammation.
Gut 63(12) , 1883-92, (2014) The dysfunction of immune regulation plays a critical role in the pathogenesis of a number of chronic inflammatory disorders, such as IBD. A close relationship between psychological stress and intestinal inflammation has been noted; the underlying mechanism r... |
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Acromegaly and pregnancy: a prospective study.
Eur. J. Endocrinol. 170(2) , 301-10, (2014) The interaction between pregnancy and acromegaly has been studied only retrospectively. We used prospective data to assess those interactions.Prospective, interventional, multicentric study.TEN PREGNANCIES IN EIGHT ACROMEGALIC PATIENTS WERE INCLUDED ACCORDING... |
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Long-term management with octreotide or cabergoline in ectopic corticotropin hypersecretion: case report and literature review.
Endocr. Pract. 16(5) , 829-34, (2010) To describe the corticotropin response to long-term octreotide or cabergoline administration in a patient with ectopic corticotropin secretion who underwent adrenalectomy.We describe the clinical, radiologic, and biochemical findings of the study patient over... |