1-Pyrenedecanoic acid
1-Pyrenedecanoic acid structure
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Common Name | 1-Pyrenedecanoic acid | ||
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| CAS Number | 64701-47-9 | Molecular Weight | 372.49900 | |
| Density | 1.158 g/cm3 | Boiling Point | 576.4ºC at 760 mmHg | |
| Molecular Formula | C26H28O2 | Melting Point | N/A | |
| MSDS | USA | Flash Point | 472.6ºC | |
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Hepatocyte free cholesterol lipotoxicity results from JNK1-mediated mitochondrial injury and is HMGB1 and TLR4-dependent.
J. Hepatol. 61(6) , 1376-84, (2014) Free cholesterol (FC) accumulates in non-alcoholic steatohepatitis (NASH) but not in simple steatosis. We sought to establish how FC causes hepatocyte injury.In NASH-affected livers from diabetic mice, subcellular FC distribution (filipin fluorescence) was es... |
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Pyrenedecanoic acid and pyrene lecithin.
Meth. Enzymol. 72 , 471, (1981)
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Metabolism of 1-pyrenedecanoic acid and accumulation of neutral fluorescent lipids in cultured fibroblasts of multisystemic lipid storage myopathy.
Biochim. Biophys. Acta 920 , 131, (1987) The lipid metabolism in cultured fibroblasts from multisystemic (type 3) lipid storage myopathy and controls has been studied through pulse-chase experiments using 1-pyrenedecanoic acid as precursor. The uptake of 1-pyrenedecanoic acid was not significantly d... |
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Measurement of membrane fluidity of polymorphonuclear leukocytes by flow cytometry.
J. Immunol. Methods 96 , 225, (1987) A method was established for measuring membrane fluidity of polymorphonuclear leukocytes (PMN) by the excimer-forming lipid technique with pyrenedecanoic acid in flow cytometry. When cells were labeled, the use of 2-25 microM of pyrenedecanoic acid provided s... |
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A gatekeeper helix determines the substrate specificity of Sjögren-Larsson Syndrome enzyme fatty aldehyde dehydrogenase.
Nat. Commun. 5 , 4439, (2014) Mutations in the gene coding for membrane-bound fatty aldehyde dehydrogenase (FALDH) lead to toxic accumulation of lipid species and development of the Sjögren-Larsson Syndrome (SLS), a rare disorder characterized by skin defects and mental retardation. Here,... |