1,5,7-Triazabicyclo[4.4.0]dec-5-ene

1,5,7-Triazabicyclo[4.4.0]dec-5-ene Structure
1,5,7-Triazabicyclo[4.4.0]dec-5-ene structure
Common Name 1,5,7-Triazabicyclo[4.4.0]dec-5-ene
CAS Number 5807-14-7 Molecular Weight 139.20
Density 1.3±0.1 g/cm3 Boiling Point 222.3±23.0 °C at 760 mmHg
Molecular Formula C7H13N3 Melting Point 125-130 °C(lit.)
MSDS Chinese USA Flash Point 88.3±22.6 °C
Symbol GHS05
GHS05
Signal Word Danger

A block copolymer of zwitterionic polyphosphoester and polylactic acid for drug delivery.

Biomater. Sci. 3 , 1105-13, (2015)

Polymeric nanoparticles have been widely used as nano-drug delivery systems in preclinical and clinical trials for cancer therapy, and these systems usually need to be sterically stabilized by poly(ethylene glycol) (PEG) to maintain stability and avoid rapid ...

Up-regulation of miR-21 and miR-23a Contributes to As2 O3 -induced hERG Channel Deficiency.

Basic Clin Pharmacol Toxicol. 116 , 516-23, (2015)

Arsenic trioxide (As2O3) is used to treat acute pro-myelocytic leukaemia. However, the cardiotoxicity of long QT syndrome restricts its clinical application. Previous studies showed that As2O3 can damage the hERG current via disturbing its trafficking to cell...

Peroxiredoxin 2 is involved in vasculogenic mimicry formation by targeting VEGFR2 activation in colorectal cancer.

Med. Oncol. 32(1) , 414, (2014)

The mammalian peroxiredoxin 2 (Prdx2) is a member of thiol-dependent antioxidant proteins and plays an important role in the progression of colorectal cancer (CRC). The aim of this study was to confirm the role of Prdx2 in formation of VM and progression of C...

Celecoxib induces epithelial-mesenchymal transition in epithelial ovarian cancer cells via regulating ZEB1 expression.

Arch. Gynecol. Obstet. 291 , 1361-9, (2015)

The purpose of our study was to investigate the therapeutic potential of Celecoxib for epithelial ovarian cancer, especially on cellular morphological changes, proliferation invasion and epithelial-mesenchymal transition (EMT).The MTT and transwell assays wer...

Neurotrophine-3 may contribute to neuronal differentiation of mesenchymal stem cells through the activation of the bone morphogenetic protein pathway.

Cell Mol. Biol. Lett. 20 , 385-403, (2015)

We investigated whether neurotrophin-3 (NT-3) can promote differentiation of mouse bone mesenchymal stem cells (MSCs) into neurons via the bone morphogenetic protein pathway. MSCs were prepared from rat bone marrow and either transfected with pIRES2-EGFP or p...

Transthyretin deposition in articular cartilage: a novel mechanism in the pathogenesis of osteoarthritis.

Arthritis Rheumatology 67 , 2097-107, (2015)

Amyloid deposits are prevalent in osteoarthritic (OA) joints. We undertook this study to define the dominant precursor and to determine whether the deposits affect chondrocyte functions.Amyloid deposition in human normal and OA knee cartilage was determined b...

Involvement of Ras GTPase-activating protein SH3 domain-binding protein 1 in the epithelial-to-mesenchymal transition-induced metastasis of breast cancer cells via the Smad signaling pathway.

Oncotarget 6 , 17039-53, (2015)

In situ models of epithelial-to-mesenchymal transition (EMT)-induced carcinoma develop into metastatic carcinoma, which is associated with drug resistance and disease recurrence in human breast cancer. Ras GTPase-activating protein SH3 domain-binding protein ...

Integration of donor mesenchymal stem cell-derived neuron-like cells into host neural network after rat spinal cord transection.

Biomaterials 53 , 184-201, (2015)

Functional deficits following spinal cord injury (SCI) primarily attribute to loss of neural connectivity. We therefore tested if novel tissue engineering approaches could enable neural network repair that facilitates functional recovery after spinal cord tra...

MicroRNA-214 suppresses oncogenesis and exerts impact on prognosis by targeting PDRG1 in bladder cancer.

PLoS ONE 10(2) , e0118086, (2015)

MicroRNA-214 (miR-214) has been reported to be dysregulated in human bladder cancer tissues. We aimed to investigate the clinical correlation, biological significance and molecular network of miR-214 in bladder cancer. Our results showed miR-214 was down-regu...

Downregulation of urinary cell-free microRNA-214 as a diagnostic and prognostic biomarker in bladder cancer.

J. Surg. Oncol. 111 , 992-9, (2015)

We aimed to investigate potential of urinary cell-free microRNA-214 (miR-214) as a noninvasive biomarker for bladder cancer in this report.We screened miR-214 expression in medium from 2 bladder cancer cell lines to determine whether it is secretory. Then we ...