Sterigmatocystine
Sterigmatocystine structure
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Common Name | Sterigmatocystine | ||
|---|---|---|---|---|
| CAS Number | 10048-13-2 | Molecular Weight | 324.284 | |
| Density | 1.5±0.1 g/cm3 | Boiling Point | 569.7±50.0 °C at 760 mmHg | |
| Molecular Formula | C18H12O6 | Melting Point | 246ºC with decomp | |
| MSDS | Chinese USA | Flash Point | 215.9±23.6 °C | |
| Symbol |
GHS06, GHS08 |
Signal Word | Danger | |
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Individual and combined effects of mycotoxins from typical indoor moulds.
Toxicol. In Vitro 27(6) , 1970-8, (2013) The mycotoxins patulin, gliotoxin and sterigmatocystin can be produced by common indoor moulds and enter the human body via inhalation of mycotoxin containing spores and particulates. There are various studies about the individual effects of these mycotoxins,... |
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Proteome analysis of the farnesol-induced stress response in Aspergillus nidulans--The role of a putative dehydrin.
J. Proteomics 75(13) , 4038-49, (2012) The isoprenoid alcohol farnesol represents a quorum-sensing molecule in pathogenic yeasts, but was also shown to inhibit the growth of many filamentous fungi. In order to gain a deeper insight into the antifungal activity of farnesol, we performed 2D-differen... |
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Involvement of MAPK and PI3K signaling pathway in sterigmatocystin-induced G2 phase arrest in human gastric epithelium cells.
Mol. Nutr. Food. Res. 55(5) , 749-60, (2011) Sterigmatocystin (ST), a mycotoxin commonly found in foodstuff and feedstuff, has been shown to be a carcinogenic mycotoxin in animal models. Many studies showed that the high level of ST contamination in grains might be related to the high incidence of gastr... |
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Deletion of the Aspergillus flavus orthologue of A. nidulans fluG reduces conidiation and promotes production of sclerotia but does not abolish aflatoxin biosynthesis.
Appl. Environ. Microbiol. 78(21) , 7557-63, (2012) The fluG gene is a member of a family of genes required for conidiation and sterigmatocystin production in Aspergillus nidulans. We examined the role of the Aspergillus flavus fluG orthologue in asexual development and aflatoxin biosynthesis. Deletion of fluG... |
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Role of nitric oxide and flavohemoglobin homolog genes in Aspergillus nidulans sexual development and mycotoxin production.
Appl. Environ. Microbiol. 77(15) , 5524-8, (2011) Flavohemoglobins are widely distributed in both prokaryotes and eukaryotes. These proteins are involved in reducing nitric oxide levels. Deletion of the Aspergillus nidulans flavohemoglobin gene fhbA induced sexual development and decreased sterigmatocystin p... |
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Distinct amino acids of histone H3 control secondary metabolism in Aspergillus nidulans.
Appl. Environ. Microbiol. 79(19) , 6102-9, (2013) Chromatin remodelling events play an important role in the secondary metabolism of filamentous fungi. Previously, we showed that a bacterium, Streptomyces rapamycinicus, is able to reprogram the histone-modifying Spt-Ada-Gcn5-acetyltransferase/ADA (SAGA/ADA) ... |
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Hydrolase controls cellular NAD, sirtuin, and secondary metabolites.
Mol. Cell. Biol. 32(18) , 3743-55, (2012) Cellular levels of NAD(+) and NADH are thought to be controlled by de novo and salvage mechanisms, although evidence has not yet indicated that they are regulated by NAD(+) degradation. Here we show that the conserved nudix hydrolase isozyme NdxA hydrolyzes a... |
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Fungal S-adenosylmethionine synthetase and the control of development and secondary metabolism in Aspergillus nidulans.
Fungal Genet. Biol. 49(6) , 443-54, (2012) The filamentous fungus Aspergillus nidulans carries a single gene for the S-adenosylmethionine (SAM) synthetase SasA, whereas many other organisms possess multiple SAM synthetases. The conserved enzyme catalyzes the reaction of methionine and ATP to the ubiqu... |
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veA-dependent RNA-pol II transcription elongation factor-like protein, RtfA, is associated with secondary metabolism and morphological development in Aspergillus nidulans.
Mol. Microbiol. 85(4) , 795-814, (2012) In Aspergillus nidulans the global regulatory gene veA is necessary for the biosynthesis of several secondary metabolites, including the mycotoxin sterigmatocystin (ST). In order to identify additional veA-dependent genetic elements involved in regulating ST ... |
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Role of hMLH1 in sterigmatocystin-induced G₂ phase arrest in human esophageal epithelial Het-1A cells in vitro.
Toxicol. Lett. 217(3) , 226-34, (2013) Sterigmatocystin (ST), a common environmental contaminant found across the world, is generally recognized as a potential carcinogen, mutagen and teratogen. Our previous epidemiological studies suggested that ST exposure might be a risk factor for esophageal c... |