Cardamonin
Cardamonin structure
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Common Name | Cardamonin | ||
|---|---|---|---|---|
| CAS Number | 19309-14-9 | Molecular Weight | 270.280 | |
| Density | 1.3±0.1 g/cm3 | Boiling Point | 484.5±45.0 °C at 760 mmHg | |
| Molecular Formula | C16H14O4 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 182.7±22.2 °C | |
| Symbol |
GHS09 |
Signal Word | Warning | |
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Palmitate-induced inflammatory pathways in human adipose microvascular endothelial cells promote monocyte adhesion and impair insulin transcytosis.
Am. J. Physiol. Endocrinol. Metab. 309 , E35-44, (2015) Obesity is associated with inflammation and immune cell recruitment to adipose tissue, muscle and intima of atherosclerotic blood vessels. Obesity and hyperlipidemia are also associated with tissue insulin resistance and can compromise insulin delivery to mus... |
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Cardamonin inhibits agonist-induced vascular contractility via Rho-kinase and MEK inhibition.
Korean J. Physiol. Pharmacol. 20 , 69-74, (2016) The present study was undertaken to investigate the influence of cardamonin on vascular smooth muscle contractility and to determine the mechanism(s) involved. Denuded aortic rings from male rats were used and isometric contractions were recorded and combined... |
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Cardamonin induces apoptosis by suppressing STAT3 signaling pathway in glioblastoma stem cells.
Tumour Biol. 36 , 9667-76, (2015) Glioblastoma stem cells (GSCs) are the initiating cells in glioblastoma multiforme (GBM) and contribute to the resistance of GBM to chemotherapy and radiation. In the present study, we investigated the effects of cardamonin (3,4,2,4-tetrahydroxychalcone) on t... |
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Effect of Alpinia katsumadai Hayata on House Dust Mite-Induced Atopic Dermatitis in NC/Nga Mice.
Evid. Based. Complement. Alternat. Med. 2012 , 705167, (2012) We evaluated the effects of Alpinia katsumadai Hayata (AKH, Zingiberaceae) extract on the production of nitric oxide (NO) and prostaglandin E(2) (PGE(2)) in RAW 264.7 cells, thymus- and-activation-regulated chemokine (TARC/CCL17) in HaCaT cells, and histamine... |
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RANKL signaling and osteoclastogenesis is negatively regulated by cardamonin.
PLoS ONE 8 , e64118, (2013) Bone loss/resorption or osteoporosis is a disease that is accelerated with aging and age-associated chronic diseases such as cancer. Bone loss has been linked with human multiple myeloma, breast cancer, and prostate cancer and is usually treated with bisphosp... |
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Immunotherapy of tumors with α2-macroglobulin-antigen complexes pre-formed in vivo.
PLoS ONE 7 , e50365, (2012) The cell surface receptor CD91/LRP-1 binds to immunogenic heat shock proteins (HSP) and α(2)M ligands to elicit T cell immune responses. In order to generate specific immune responses, the peptides chaperoned by HSPs or α(2)M are cross-presented on MHC molecu... |
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Cardamonin reduces chemotherapy-enriched breast cancer stem-like cells in vitro and in vivo.
Oncotarget 7 , 771-85, (2016) The failure of cytotoxic chemotherapy in breast cancers has been closely associated with the presence of drug resistant cancer stem cells (CSCs). Thus, screening for small molecules that selectively inhibit growth of CSCs may offer great promise for cancer co... |